Clone: ZR395
Host clonality: rabbit monoclonal
Control tissue: pancreas, appendix/colon, and selective neuroendocrine neoplasm
Staining pattern: nuclear
Regulatory status: IVD, FDA Class 1
|
Product code:
|
8379-C010: RTU, 10 capsules; 1 pack
8379-M250: RTU, 250 tests, 1 cartridge; 1 unit
|
The Tissue-Tek Genie® anti-INSM1 Rabbit Monoclonal Antibody [ZR395] is designed to qualitatively detect INSM1 protein in formalin-fixed, paraffin-embedded (FFPE) human tissue specimen sections by immunohistochemistry (IHC) staining on the automated Tissue-Tek Genie® Advanced Staining System.
This device functions as an aid for diagnosis and shall be used by a qualified pathologist with a panel of other antibodies to identify neuroendocrine neoplasms. Recent studies suggest that INSM1 is a highly specific biomarker for neuroendocrine differentiation, demonstrating greater specificity than chromogranin A (CGA) and comparable or superior sensitivity to synaptophysin (SYP) and CD56. INSM1 is detected in neoplastic cells of neuroendocrine neoplasms, including small cell lung carcinoma and medullary thyroid carcinoma.
.jpg?lang=en-US "Tissue-Tek Genie anti-INSM1")
Distinct nuclear positivity in the neoplastic cells of small cell lung carcinoma.
.jpg "INSM1-2-(2).jpg")
Moderate to strong nuclear positivity in the endocrine cells of pancreatic Islets of Langerhans.
.jpg "INSM1-3-(2).jpg")
No staining in neoplastic cells of melanoma.
.jpg "INSM1-4-(2).jpg")
Distinct, strong nuclear positivity in the neuroendocrine cells of appendiceal mucosa.