Clone: CCP58
Host clonality: mouse monoclonal
Control tissue: appendix, colon, small intestine
Staining pattern: cytoplasmic
Regulatory status: IVD, FDA Class I
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Product code:
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8305-C010: RTU, 10 capsules; 1 pack
8305-M250: RTU, 250 tests, 1 cartridge; 1 unit
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The Tissue-Tek Genie® anti-MUC2 Mouse Monoclonal Antibody [CCP58] is designed to qualitatively detect MUC2 protein in formalin-fixed, paraffin-embedded (FFPE) human tissue specimen sections by immunohistochemistry (IHC) staining on the automated Tissue-Tek Genie® Advanced Staining System. This device functions as an aid for diagnosis and shall be used by a qualified pathologist with a panel of other antibodies to identify adenocarcinoma of gastrointestinal origin and to differentiate metastatic colorectal adenocarcinoma from primary ovarian carcinoma. MUC2 is a well-established mucin marker found across a broad spectrum of gastrointestinal and other mucinous tumors. It is frequently expressed in primary GI cancers, including those of colonic, gastric, and esophageal origin. Evidence indicates that MUC2 is useful for identifying mucinous subtypes of colorectal and gastric adenocarcinomas. In contrast, non-mucinous ovarian carcinomas typically lack MUC2 expression.
Cytoplasmic positivity in the neoplastic cells of colorectal carcinoma.
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Moderate to strong cytoplasmic staining of epithelial goblet cells in appendix/colon.
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Cytoplasmic positivity of neoplastic epithelial cells in colorectal carcinomas.
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No staining in neoplastic cells on non-mucinous ovarian carcinomas.