Compression: distorted or folded appearance.

Compression: distorted or folded appearance

Causes and remedies

  • Cutting too fast
    Slow down sectioning speed
  • Block too warm
    Chill on ice or cold tray
  • Dull blade
    Move to an unused area of the blade, or insert a new blade
  • Locking mechanisms loose on microtome
    Verify locking mechanisms are tight
  • Blade angle too high
    Reduce blade angle in 1-degree increments
Microscopic image of kidney tissue showing glomeruli and tubules stained with pink and purple hues.

Compression: distorted or folded appearance Causes and remedies