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Tissue-Tek Genie® Advanced Staining Reagents

Product catalog

Quality is US – How we ensure optimal stain quality and scores for our antibodies

Laboratories are looking for staining slides with IHC assays that provide high sensitivity and high specificity to maximize diagnostic utility. Furthermore, they request consistent stain quality, slide after slide, especially important to always correctly detect low expressors. We devote our resources to produce reagents that always deliver optimal performance with a lot to lot consistency.

We have designed and implemented a straight forward process to develop robust assays with the following steps:

  • Define the intended use and diagnostic utility of the assay
  • Determine adequate control material
  • Define acceptance criteria
  • Identify best clone candidates
  • Selection for each the best antigen retrieval
  • Define for each the best dilution of the antibody and the incubation times for all the steps of the factory validated protocol
  • Validate diagnostic performance internally and externally

Like NordiQC, a professional and scientific organization that promotes the quality of immunohistochemistry and expands its clinical use by arranging schemes for immunohistochemical proficiency testing, we publish the results from our validation studies on our own website called Advanced Staining Gallery to display assay performance scored optimal and enable laboratories to appreciate our daily work for you with full transparency.

We collaborate with a proficiency testing institute for external independent review and confirmation of successful fulfillment of the assessment and acceptance criteria, and for confirmation that the assay performance was scored optimal. As an example, please see the assessment / acceptance criteria for PMS2 applied and explained to the right.

PMS2, like MSH6, MSH2 and MLH1, was scored optimal in the latest proficiency test runs of NordiQC (NordiCQ).

Microscopic image showing cross-sections of glandular tissue with dark-stained cell nuclei arranged around circular and oval-shaped structures.

At least weak to moderte, distinct nuclear staining reaction of virtually all cells in the appendix.

A close-up of a cell.

A moderate to strong, distinct nuclear staining raction of virtually all neoplastic cells in the colon adenocarcinoma.

A close-up of a cell.

At least weak to moderate, distinct nuclear staining reaction of virtually all mantle zone B-cells and a moderate to strong, distinct nuclear staining reaction of the germinal center B-cells in the tonsil.

A close-up of a cell.

No nuclear staining reaction of the neoplastic cells in the colon adenocarcinomas, but a weak to moderate distinct nuclear staining reaction in the vast majority of other cells (stromal cells, lymphocytes etc.).

The innovative single-use Capsules make Genie the most convenient stainer on the market, eliminating batching and sorting of slides, and giving you the flexibility to load any slide, any stain, any time, any station on any Genie.

A hand in a glove holding a device.

Benefit from using Capsules:

  1. Run cases or single slides without the need to batch slides by antibody
  2. Save time loading slides whenever a staining station is available
  3. Use for any slide volume of any biomarkers

The capsule is mounted to the Tissue-Tek Genie® Reagent Dispense Area (RDA) with its attached protocol RDA-Tag and both are loaded into an empty stain station.

Three close-up images show a green capsule held with forceps, and a fourth image shows the capsule placed in a labeled container reading "DUO Pan-CK/CD31".

In summary, this innovative technology enables laboratories to quickly load slides and reagents for an IHC stain to gain continuous workflow with short and predictable TAT.

Product code

Product name and quantity

8637-K001

Tissue-Tek Genie® RDA-Tag Label Kit; 1 ribbon and 2 rolls of 2,400 RDA-Tag labels; 1 kit

8616-G090

Tissue-Tek Genie® Reagent Dispense Area [RDA]; 90 RDAs; 1 box

8618-G090

Tissue-Tek Genie® Reagent Dispense Area Tag [RDA-Tag]; 90 RDA-Tags; 1 box

8636-K001

Tissue-Tek Genie® Slide Label Kit; 1 ribbon and 3 rolls of 3,000 slide labels; 1 kit

8642-G001

Tissue-Tek Genie® Storage and Transport Tray, Blue; 1 unit

8641-G001

Tissue-Tek Genie® Storage and Transport Tray, Red; 1 unit

8217-G004

Tissue-Tek Genie® Waste Bottles

8643-G001

Tissue-Tek Genie® Workflow Organizer; 1 unit

9036

Tissue-Tek® SmartWrite® White Frosted Slides – Charged; 100/box; 10 boxes/case

9046

Tissue-Tek® SmartWrite® Blue Frosted Slides – Charged, 100/box; 10 boxes/case

9048

Tissue-Tek® SmartWrite® Green Frosted Slides – Charged, 100/box; 10 boxes/case

9050


Tissue-Tek® SmartWrite® Lavender Frosted Slides – Charged, 100/box; 10 boxes/case

9052

Tissue-Tek® SmartWrite® Pink Frosted Slides – Charged, 100/box; 10 boxes/case

9054

Tissue-Tek® SmartWrite® Yellow Frosted Slides – Charged, 100/box; 10 boxes/case

9809-G006

Tissue-Tek Genie® CISH User-Fillable Cartridges for CISH Amplification Linker; 6 cartridges/box

8610-K050

Genie® User-Fillable Capsule Sealing System; 1 kit

8622-G006

Tissue-Tek Genie® User-Fillable Cartridge for Biomarker-Binding Reagent, 6 cartridges/box; 1 box

8611-G002

Tissue-Tek Genie® User-Fillable Capsule Tray, 2/box; 1 box

8615-G001

Tissue-Tek Genie® User-Fillable Capsule Sealer; 1 unit

8619-K100

Tissue-Tek Genie® User-Fillable Capsules and Seals, 100 capsules, 130 seals; 1 kit

Sakura Finetek offers 160 high quality primary antibodies and probes specifically developed to provide high sensitivity and specificity when used with the Tissue-Tek Genie Advanced Staining System. This ensures that users are provided with consistent, quality staining results and reproducibility that clinical laboratories have come to expect from Sakura Finetek IHC & ISH advanced staining products.  These staining results were independently evaluated by a leading quality assurance organization to maximize diagnostic utility and provide optimal stain quality.

Discover our complete line of organ specific antibodies by clicking the buttons below.

Complete printable primary antibody list
Derm path
Gastrointestinal path
Breast path
Lung path
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Search Primary Antibodies

131 primary antibodies found
Product Code: 8302-C010: RTU, 10 capsules; 1 pack
8302-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: DC10
Host Clonality: mouse monoclonal
Control Tissue: liver, gastrointestinal tract, and known CK 18 positive tumors
Staining Pattern: cytoplasmic and sometimes membraneous
Regulatory Status: IVD, FDA Class I
Cytokeratin 18 (CK18) is expressed in simple, non-stratified epithelia, in transitional epithelium, and in the luminal/secretory cells of complex epithelia. It is often co-expressed with CK8.
Tissue-Tek Genie<sup>® </sup> anti-Cytokeratin 18
Additional Images:
Microscopic view of stained tissue sample showing brown-stained cells with blue nuclei, highlighting cell structure and distribution for histological analysis. Microscopic view of stained tissue cells showing brown and blue coloration, with irregular cell shapes and clustered nuclei. Microscopic image of a tissue section showing multiple layers of cells with some brown-stained areas on the left side and predominantly blue-stained nuclei throughout. Microscopic image of tissue section showing multiple layers of cells with varying staining intensity, likely from an immunohistochemistry analysis.
Product Code: 8326-C010: RTU, 10 capsules; 1 pack
8326-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP49
Host Clonality: rabbit monoclonal
Control Tissue: colon, appendix, tonsil
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
MSH6 is expressed in normal proliferating cells and, when heterodimerized with MSH2 (MutS homolog 2), is involved in repairing DNA mutations which may occur during DNA replication.
Tissue-Tek Genie<sup>® </sup> anti-MSH6
Additional Images:
Microscopic view of tissue sample showing densely packed, dark-stained cell nuclei arranged in wavy, layered patterns on a light background. Microscopic view of tissue sample stained to highlight cell nuclei and structures; elongated and oval shapes are visible with dark spots indicating nuclei. Microscopic image showing densely packed, dark-stained cell nuclei arranged in glandular structures, typical of tissue viewed under high magnification. Microscopic image of tissue section stained to show cell nuclei in brown and cytoplasm in light blue, highlighting cellular and structural details.
Product Code: 8502-C010: RTU, 10 capsules; 1 pack
8502-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP298
Host Clonality: rabbit monoclonal
Control Tissue: kidney, endometrium, PAX8 positive RCC, and ono-mucineous ovarian cancer
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
PAX8 is a transcription factor that is important for organogenesis and development of the thyroid, urogenital tract, and placenta. PAX8 is expressed in epithelial cells of the urogenital tract and thyroid.
Tissue-Tek Genie<sup>® </sup> anti-PAX8
Additional Images:
Microscopic view of tissue sample showing numerous dark-stained nuclei scattered throughout a lighter background, consistent with immunohistochemical staining. Microscopic image of tissue showing numerous dark brown stained cell nuclei scattered throughout a pale background, likely from an immunohistochemistry slide. Microscopic view of tissue sample stained in shades of blue and white, showing cellular structures and various densities throughout the image. Microscopic image showing dense clusters of small blue cells scattered throughout a light purple background, suggestive of tissue stained for cellular or histological analysis.
Product Code: 8292-C010: RTU, 10 capsules; 1 pack
8292-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: 1A4
Host Clonality: mouse monoclonal
Control Tissue: stomach, small Intestine, colon, appendix, myogenic tumors with know alpha actin expression
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Actins are cytoskeletal proteins that are involved in cell motility and are universally expressed by, and highly conserved in, all eukaryotic cells. Most cell types express the beta and gamma actins, which are involved in internal cell motility. The alpha actins are found mainly in muscle tissues where they comprise part of the contractile apparatus.
Tissue-Tek Genie<sup>®</sup> anti-Actin, Smooth Muscle
Additional Images:
Microscopic view of tissue with scattered blue-stained nuclei and brown-stained branching structures, likely showing immunohistochemical staining. Microscopic view of tissue sample stained to highlight cell structures; brown staining marks certain regions among clusters of blue-stained cell nuclei. Microscope image showing scattered small round cells with nuclei and a few larger, dark-stained oval structures on a pale background. Microscopic view of tissue with scattered small round cells and a few larger, irregular darkly stained structures against a light background.
Product Code: 8350-C010: RTU, 10 capsules; 1 pack
8350-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: 1A4
Host Clonality: mouse monoclonal
Control Tissue: appendix, ALK positive ALCL
Staining Pattern: cytoplasmic and/or nuclear staining
Regulatory Status: IVD, FDA Class I
Anaplastic Lymphoma Kinase (ALK) is a transmembrane receptor tyrosine kinase. In normal tissue ALK is expressed in cells within a developing and mature nervous system including glial cells, neurons, endothelial cells, and pericytes. ALK was originally discovered as part of a fusion protein with nucleophosmin (NPM) produced by a translocation between the NPM and ALK genes and is the ALK fusion protein primarily associated with anaplastic large cell lymphoma (ALCL).
Tissue-Tek Genie<sup>®</sup> anti-ALK (Heme)
Additional Images:
Microscopic image showing densely packed brown-stained cells with a lighter, irregular band running diagonally across the center. Microscopic image showing densely packed brown-stained cells with a light, fibrous band running diagonally through the center. Microscopic view of tissue section stained with blue and brown dyes, showing densely packed cell nuclei and fibrous structures. Microscopic image of tissue showing densely packed blue-stained cell nuclei and scattered brown-stained cells among fibrous structures.
Product Code: 8291-C010: RTU, 10 capsules; 1 pack
8291-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: 13H4
Host Clonality: rabbit monocolonal
Control Tissue: prostate adenocarcinoma
Staining Pattern: granular and cytoplasmic
Regulatory Status: IVD, FDA Class I
AMACR, also known as P504S, is a mitochondrial enzyme expressed in many normal epithelia such as hepatocytes, tubular epithelia of kidney, epithelia of gall bladder, bronchial epithelia of lung, and colonic surface epithelia.
Tissue-Tek Genie<sup>®</sup> anti-AMACR
Additional Images:
Microscopic view of tissue section showing glandular structures on the left and fibrous connective tissue with scattered cells on the right. Microscopic image of tissue showing glandular structures on the left and dense connective tissue with scattered cells on the right, stained for histological examination.
Product Code: 8459-C010: RTU, 10 capsules; 1 pack
8459-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP36
Host Clonality: rabbit monoclonal
Control Tissue: Tonsil
Staining Pattern: Cytoplasmic
BCL2 is a mitochondrial membrane protein expressed in lymphoid tissues (B-cells in mantle zone, interfollicular T-cell areas, and very few cells in the germinal center), and basal cells of epithelial tissues.
Tissue-Tek Genie<sup>®</sup> anti-BCL2
Additional Images:
Microscopic image showing a tissue section with densely packed dark-stained cells in the lower region and lighter-stained cells in the upper region. Microscopic image of tissue showing densely packed dark brown stained cells in the lower region and lighter stained cells in the upper region. Microscopic image showing densely packed brown-stained cells, likely from a tissue sample prepared with immunohistochemical staining. Microscopic view of densely packed, dark brown stained cells, likely from a tissue sample prepared for histological examination.
Product Code: 8461-C010: RTU, 10 capsules; 1 pack
8461-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP278
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, some B-cell lymphomas
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
BCL6 is a transcription factor essential for germinal center formation in lymphoid tissue.
Tissue-Tek Genie<sup>®</sup> anti-BCL6
Additional Images:
A microscopic view of tissue stained with numerous small, dark brown dots evenly distributed across a light background. Microscopic view of cells stained with a brown dye, scattered densely across a light background, commonly seen in immunohistochemistry slides. Microscopic image showing a dense field of brown-stained cells interspersed with lighter areas, indicative of immunohistochemical staining in tissue. Microscopic view of tissue stained with brown and blue hues, showing dense cellular structures and varying texture patterns across the sample.
Product Code: 8261-C010: RTU, 10 capsules; 1 pack
8261-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP35
Host Clonality: rabbit monoclonal
Control Tissue: liver, appendix, colon adenocarcinoma, fibromatosis lesions
Staining Pattern: nuclear, cytoplasmic, and membraneous
Regulatory Status: IVD, FDA Class I
Beta-catenin protein is a cell adhesion molecule that forms catenin-cadherin complex through binding the epithelial cadherin (E-cadherin) protein at juxtamembrane sites. It is normally found in the cytoplasm at a submembraneous location, but mutations in the beta-catenin gene can result in nuclear accumulation of the protein as has been demonstrated in fibromatosis lesions and in colorectal carcinoma.
Tissue-Tek Genie<sup>®</sup> anti-beta-Catenin
Additional Images:
Microscopic image showing hexagonal cells with visible nuclei stained blue and a central light area, likely depicting tissue section with cell boundaries and a duct or vessel. Microscopic image of tissue showing polygonal cells with dark-stained boundaries and nuclei surrounding a lighter, irregularly shaped central area. Microscopic image of tissue showing stained cells with brown and blue coloration, displaying varying cell densities and structures. Microscopic image showing stained tissue with scattered dark blue nuclei and brown cell membrane staining, likely from immunohistochemistry analysis.
Product Code: 8462-C010: RTU, 10 capsules; 1 pack
8462-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: ZM74
Host Clonality: mouse monoclonal
Control Tissue: tonsil, DLBCL, follicle center lymphoma
Staining Pattern: cytoplasmic and nuclear
Regulatory Status: IVD, FDA Class I
BOB.1 is a B-cell specific coactivator and interacts with OCT.1 and OCT.2 transcription factors. The expression of BOB.1 is limited largely to mature B-cells in germinal centers and mantle zones, as well as plasma cells. The expression of BOB.1 in B-cell tumors is variable. Lymphocyte predominant (LP) cells in nodular lymphocyte predominant Hodgkin lymphoma are BOB.1 positive. In B-cell lymphomas, the highest expression levels for BOB.1 are in follicle center lymphomas, diffuse large B-cell lymphomas (DLBCL) and Burkitt lymphomas.
Tissue-Tek Genie<sup>®</sup> anti-BOB.1
Additional Images:
Microscopic view of tissue sample with blue-stained cell nuclei and scattered brown-stained cells, indicating immunohistochemical staining. Microscopic image of tissue stained to show cell nuclei in blue and scattered brown signals indicating specific marker presence. Microscopic image of densely packed brown-stained cells, likely from a tissue sample, with varying shades and some lighter areas interspersed throughout. Microscopic view of tissue stained brown with numerous densely packed cells, possibly from an immunohistochemistry assay.
Product Code: 8332-C010: RTU, 10 capsules; 1 pack
8332-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP121
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, c-Myc positive B-cell lymphoma
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
C-Myc is expressed during proliferation in a wide variety of adult tissues and at all stages of embryonic development. C-Myc gene translocations to various chromosomal loci have been demonstrated in Burkitt lymphoma, diffuse large B-cell lymphoma, blastic mantle cell lymphoma, and transformed follicular lymphoma. C-Myc expression has been described in various cancers including lymphomas, breast, prostate, lung and colon cancers.
Tissue-Tek Genie<sup>®</sup> anti-c-Myc
Additional Images:
Microscopic view of two layers of elongated cells with oval nuclei, some stained dark brown and others light blue, separated by a clear gap. Microscopic image of tissue sections showing elongated cells with dark-stained nuclei and lighter cytoplasm, separated by a clear gap in the center. Microscopic view of human pancreatic tissue showing numerous cell nuclei stained dark blue against a light background. Microscopic view of cells with prominent nuclei, stained in purple and blue, showing cell structure and distribution.
Product Code: 8364-C010: RTU, 10 capsules; 1 pack
8364-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: QR098
Host Clonality: rabbit monoclonal
Control Tissue: appendix, pancreas, or colorectal carcinoma
Staining Pattern: predominantly membranous
Regulatory Status: IVD, FDA Class I

Cadherin 17 (CDH17), also known as liver-intestinal cadherin (LIcadherin), is a transmembrane glycoprotein involved in cell adhesion.

Tissue-Tek Genie<sup>®</sup> anti-Cadherin 17
Product Code: 8310-C010: RTU, 10 capsules; 1 pack
8310-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP63
Host Clonality: rabbit monoclonal
Control Tissue: gastrointestinal tract, normal breast
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Calponin is a protein involved in the regulation of smooth muscle contraction and is expressed exclusively to vascular and visceral smooth muscle cells.
Tissue-Tek Genie<sup>®</sup> anti-Calponin
Additional Images:
Microscopic image showing stained tissue, with dense brown-stained regions and lighter areas containing numerous blue cell nuclei. Microscopic image showing brown-stained cells in the lower area and blue-stained nuclei in the upper area, indicating different tissue types or cell markers. Microscopic image of tissue stained with hematoxylin and eosin, showing blue-purple cell nuclei and cytoplasm in a clustered, branching pattern. Microscopic image showing blue-stained tissue structures with cellular detail and multiple small, circular cells scattered throughout on a light background.
Product Code: 8522-C010: RTU, 10 capsules; 1 pack
8522-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: RM324
Host Clonality: rabbit monoclonal
Control Tissue: appendix, colon, mesothelioma
Staining Pattern: cytoplasmic and nuclear
Regulatory Status: IVD, FDA Class I
Calretinin is a calcium-binding protein that is expressed in both central and peripheral neural tissues, mesothelium, eccrine glands of skin, Sertoli cells of the testis, ovarian stromal cells, and adrenal cortical cells.
Tissue-Tek Genie<sup>®</sup> anti-Calretinin
Additional Images:
Microscopic view of stained liver tissue showing hepatocytes with brown areas indicating positive staining and blue nuclei throughout the sample. Microscopic image of tissue showing cells with brown staining in some areas and lighter areas elsewhere; cell nuclei appear as small blue dots throughout the sample. Microscopic image showing clusters of light blue-stained cells with varying shapes and sizes, scattered among other smaller, darker-stained cells. Microscopic view of stained cellular tissue showing clusters of cells with prominent nuclei and surrounding extracellular matrix.
Product Code: 8253-C010: RTU, 10 capsules; 1 pack
8253-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: GM003
Host Clonality: mouse monoclonal
Control Tissue: normal tonsil, small intestine
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
CD10, also known as common acute lymphoblastic leukemia antigen (CALLA), is a cell surface metallopeptidase expressed on early lymphoid progenitors, a small subset of immature B-cells, proliferating B-cells and mature neutrophils.
No image available
Product Code: 8267-C010: RTU, 10 capsules; 1 pack
8267-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP10
Host Clonality: rabbit monoclonal
Control Tissue: appendix, colon, GIST
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
CD117, also known as c-kit, is a transmembrane protein expressed on hematopoietic stem/progenitor cells, interstitial cells of Cajal, mammalian ductal epithelia, melanocytes, mast cells and basal cells of skin.
Tissue-Tek Genie<sup>®</sup> anti-CD117 (c-kit)
Additional Images:
Microscopic view of numerous brown-stained cells with irregular shapes and sizes, densely packed across the field. Microscopic view of densely packed cells with brown staining, showing varying cell shapes and sizes, possibly indicating tissue or histological sample. Microscopic view of tissue stained with hematoxylin and eosin, showing varying cell densities and structures in blue and purple hues. Microscopic view of tissue stained with a blue and white histological dye, showing cell structures and varying densities across the sample.
Product Code: 8503-C010: RTU, 10 capsules; 1 pack
8503-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP117
Host Clonality: rabbit monoclonal
Control Tissue: appendix, bone marrow, liver and selected cases of AML
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
CD13 is a heavily glycosylated membrane protein expressed by most cells of myeloid origin including monocytes, macrophages, granulocytes, and their hematopoietic precursors. CD13 is also abundantly expressed in the brush border of epithelial cells (e.g., renal proximal tubules, small intestine, prostatic epithelial cells), bile duct canaliculi, mast cells, bone marrow stromal cells, osteoclasts, in fibroblasts, and smooth muscle cells.
Tissue-Tek Genie<sup>®</sup> anti-CD13
Additional Images:
Microscope image showing clusters of irregularly shaped, densely packed cells stained in dark brown and blue tones. Microscopic image showing densely clustered cells with brown and blue staining, some clear circular spaces, and irregular granular texture. Microscopic image of kidney tissue showing glomeruli and tubules, with dark brown staining highlighting specific protein expression. Microscopic image showing kidney tissue with dark brown-stained regions indicating protein expression, and lighter areas representing unstained or less active tissue.
Product Code: 8241-C010: RTU, 10 capsules; 1 pack
8241-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: B-A38
Host Clonality: mouse monoclonal
Control Tissue: tonsil, appendix, plasmacytoma, and CD138 positive DLBCL
Staining Pattern: mainly membraneous and some cytoplasmic
Regulatory Status: IVD, FDA Class I
CD138, also known as Syndecan-1, is a membrane protein which is involved in regulating cell morphology and adhesion. CD138 is predominantly expressed on mature plasma cells and early pre B-cells, in plasma cell malignancies, but not in mature mesenchymal and neural tissues. Various types
of epithelial cells are CD138 positive.
Tissue-Tek Genie<sup>®</sup> anti-CD138
Additional Images:
Close-up view of a tissue sample under a microscope, showing densely packed, polygonal cells stained in brown and blue. A microscopic view of densely packed polygonal cells with brown borders and blue-purple centers, showing a uniform, honeycomb-like tissue structure. Microscopic image showing a cluster of small, densely packed blue-stained cells adjacent to larger, empty-looking white adipose cells. Microscopic image shows adipose tissue with large clear cells on the left and densely packed blue-stained cells, possibly lymphocytes, on the right.
Product Code: 8321-C010: RTU, 10 capsules; 1 pack
8321-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP128
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, appendix, liver
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
CD14 is expressed on monocytes, macrophages, follicular dendritic cells, histiocytes, and Langerhans’ cells. CD14 is detected in myeloid leukemias with monoblastic/monocytic differentiation, histiocytic neoplasms, Langerhans’ cell histiocytosis, and giant cell tumors. CD14 is more specific than CD68 in the identification of monocytes/histiocytes and associated neoplasms.
Tissue-Tek Genie<sup>®</sup> anti-CD14
Additional Images:
Microscopic view of tissue sample showing densely packed cells stained blue, with a lighter central area and darker brown-stained regions on the right side. Microscopic image of a tissue section showing densely packed round cells stained blue, with some brown-stained areas mainly concentrated on the right side of the image. Microscopic view of tissue section showing numerous small, round, blue-stained cell nuclei scattered throughout a light-colored background, with some darker brown elongated structures. Microscopic image of tissue section showing numerous small, round, blue-stained nuclei and scattered brown-stained areas on a pale background.
Product Code: 8256-C010: RTU, 10 capsules; 1 pack
8256-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: MMA
Host Clonality: mouse monoclonal
Control Tissue: tonsil, appendix, kidney, classical Hodgkin lymphoma, and lung adenocarcinoma
Staining Pattern: cytoplasmic and membraneous
Regulatory Status: IVD, FDA Class I
CD15 is a membrane protein expressed by most terminally differentiated myeloid cells. Activated lymphocytes are CD15 protein positive, but the majority of lymphocytes are CD15 protein negative.
Tissue-Tek Genie<sup>®</sup> anti-CD15
Additional Images:
Microscopic image of tissue section stained to highlight cellular structures, showing densely packed blue nuclei and a brown-stained fibrous region along the edge. Microscopic image of tissue section stained to highlight brown immunohistochemical markers along the edge, with blue-stained cell nuclei visible throughout the sample. Histological slide showing numerous small, blue-stained cells with scattered dark brown-stained areas throughout the tissue sample. Microscopic image showing clusters of brown-stained cells among many blue-stained cells, commonly seen in immunohistochemistry tissue analysis.
Product Code: 8245-C010: RTU, 10 capsules; 1 pack
8245-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP324
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, appendix, liver, CD163 positive dermatofibromas
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
CD163 is a membrane protein that has anti-inflammatory functions and is expressed by cells of the monocyte/macrophage lineage. It is found in a majority of acute myeloid leukemia cases with monocytoid differentiation and histiocytic sarcoma.
Tissue-Tek Genie<sup>®</sup> anti-CD163
Additional Images:
Microscopic view of densely packed blue-stained cells with some darker brown-stained regions on the left and lower edges. Microscopic image showing densely packed cells stained in varying shades of blue and some brown areas, likely representing a tissue sample. Microscopic image of kidney tissue showing multiple glomeruli with scattered blue-stained cell nuclei and brown immunohistochemical staining throughout the tissue. Microscopic image of kidney tissue showing glomeruli and tubules with stained cell nuclei, highlighting cellular structures for histological analysis.
Product Code: 8516-C010: RTU, 10 capsules; 1 pack
8516-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP169
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, appendix, and B-cell neoplasms
Staining Pattern: membraneous
Regulatory Status: IVD, FDA Class I
CD19 regulates B-cell development, activation, and differentiation. CD19 is widely expressed from early pre-B-cells, normal B-cells, and normal plasma cells. Its expression on normal plasma cells is weaker than normal B-cells and a subpopulation may lack expression. CD19 is also expressed on follicular dendritic cells. CD19 is a specific and sensitive marker of B-cells and is found on the majority of B-cell neoplasms.
Tissue-Tek Genie<sup>®</sup> anti-CD19
Additional Images:
Microscopic view of densely packed, round cells stained brown and purple, showing a uniform pattern across the image. Microscopic image showing densely packed, round cells with dark brown staining and some lighter blue areas; indicates cell clusters or tissue sample under magnification. Microscopic view of numerous round, blue-stained cells evenly distributed across a light background. Microscopic image showing numerous round, blue-stained cells evenly distributed across a light background.
Product Code: 8246-C010: RTU, 10 capsules; 1 pack
8246-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP80
Host Clonality: rabbit monoclonal
Control Tissue: thymus, skin
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
CD1a is a cell surface protein expressed on dendritic cells, cortical thymocytes, Langerhans cells skin, and some epithelia.
Tissue-Tek Genie<sup>®</sup> anti-CD1a
Additional Images:
Microscopic image showing densely packed blue and brown-stained cells, likely highlighting cellular differences in a tissue sample. Microscopic image showing densely packed blue-stained cells with clusters of dark brown-stained cells, indicating differential cellular or protein expression. Microscopic image of a tissue sample stained with blue dye, showing densely packed cells with varying intensity and some lighter regions. Microscopic image of tissue stained with hematoxylin, showing densely packed blue cells with a lighter oval-shaped region in the center.
Product Code: 8255-C010: RTU, 10 capsules; 1 pack
8255-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP222
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, appendix, some T-cell lymphomas
Staining Pattern: membraneous
Regulatory Status: IVD, FDA Class I
CD2 a transmembrane protein expressed on the majority of thymocytes and peripheral T-lymphocytes, and is considered a pan T-cell antigen.
Tissue-Tek Genie<sup>®</sup> anti-CD2
Additional Images:
Microscopic image of tissue with blue-stained cells and scattered dark brown spots, possibly showing immunohistochemical staining results. Microscopic image of tissue stained with blue and brown dyes, showing cell nuclei and darker spots scattered throughout the sample.
Product Code: 8259-C010: RTU, 10 capsules; 1 pack
8259-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: L26
Host Clonality: mouse monoclonal
Control Tissue: tonsil
Staining Pattern: membraneous
Regulatory Status: IVD, FDA Class I
CD20 is a transmembrane protein expressed on B-cell precursors and mature B-cells, but is lost in plasma cells. CD20 is almost always expressed in B-cell lymphomas.
Tissue-Tek Genie<sup>®</sup> anti-CD20
Additional Images:
Microscopic image of tissue stained with immunohistochemistry, showing scattered dark brown spots among numerous small blue cells. Microscopic image of tissue stained with brown markers highlighting specific cells among a larger number of blue-stained cells.
Product Code: 8260-C010: RTU, 10 capsules; 1 pack
8260-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP64
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, lymph node
Staining Pattern: membraneous
Regulatory Status: IVD, FDA Class I
CD21 is a membrane protein that serves as the receptor for complement component C3 (C3d) and the Epstein-Barr Virus (EBV). CD21 is expressed on dendritic cells and mature B-cells.
Tissue-Tek Genie<sup>®</sup> anti-CD21
Additional Images:
Microscopic image of tissue showing densely packed, dark-stained cells surrounded by lighter-stained areas, commonly seen in immunohistochemistry slides. Microscopic image showing a densely-packed cluster of cells surrounded by lighter tissue, possibly indicating a lymph node or a tissue sample under immunohistochemical staining.
Product Code: 8262-C010: RTU, 10 capsules; 1 pack
8262-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: GR013
Host Clonality: rabbit monoclonal
Control Tissue: tonsil or known CD23 positive B-cell lymphoma
Staining Pattern: membraneous and some cytoplasmic
Regulatory Status: IVD, FDA Class I
CD23 is type II membrane glycoprotein and is primary expressed on the surface of a sub-population of B-cells in germinal center (mantle zone, and follicular dendritic cells). In tonsil, membrane staining is observed with follicular dendritic cells in germinal centers and activated B-cells in the mantle zones around germinal centers.
Tissue-Tek Genie<sup>®</sup> anti-CD23
Additional Images:
Microscopic image showing a dense, dark-stained cluster of cells surrounded by lighter-stained tissue, likely representing a lymphoid follicle or similar structure. Microscopic image showing a cluster of dark-stained cells within lighter-stained tissue, likely highlighting a specific cell type or structure in a biological sample. Microscopic view of densely packed small round cells with dark nuclei on a light background, typical of a hematologic tissue sample. Microscopic view of numerous small, round, purple-stained cells densely packed together on a light background.
Product Code: 8280-C010: RTU, 10 capsules; 1 pack
8280-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP177
Host Clonality: rabbit monoclonal
Control Tissue: tonsil
Staining Pattern: membraneous
Regulatory Status: IVD, FDA Class I
CD3 is a complex of membrane proteins composed of five polypeptide chains that associate directly with the T-cell antigen receptor. CD3 is expressed on T-lymphocytes in the thymus, bone marrow, peripheral lymphoid tissue and blood.
Tissue-Tek Genie<sup>®</sup> anti-CD3
Additional Images:
Microscopic image showing several oval-shaped glandular structures surrounded by densely packed dark-stained cells on a light background. Microscopic view of tissue with several oval-shaped structures and densely clustered dark-stained cells scattered throughout the image.
Product Code: 8265-C010: RTU, 10 capsules; 1 pack
8265-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: Ber-H2
Host Clonality: mouse monoclonal
Control Tissue: Hodgkin lymphoma and ALCL
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
CD30 is a transmembrane protein expressed on scattered large activated B- and T-lymphocytes in tonsil, lymph nodes, spleen, and thymus.
Tissue-Tek Genie<sup>®</sup> anti-CD30
Additional Images:
Microscopic view of tissue stained with brown and blue dyes, showing clusters of cells with varying coloration. Microscopic image of tissue sample showing clusters of dark brown-stained cells among lighter blue-stained cells, indicating differential protein expression. Microscopic image showing densely packed, round blue cells with a few scattered brownish-stained spots on a pale background. Microscopic image of densely packed blue-stained cells, likely representing lymphocytes in tissue, with occasional brown-stained areas.
Product Code: 8268-C010: RTU, 10 capsules; 1 pack
8268-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: QBEnd/10
Host Clonality: mouse monoclonal
Control Tissue: normal appendix, tonsil, liver
Staining Pattern: membraneous
Regulatory Status: IVD, FDA Class I
CD34 is a transmembrane protein expressed on hematopoietic progenitor cells, capillary endothelial cells, rare glial cells in nervous tissues, and embryonic fibroblasts. The antibody recognizes a CD34 epitope that is resistant to neuraminidase, and sensitive to glycoprotease and chymopapain.
Positive tissue
Tissue-Tek Genie<sup>®</sup> anti-CD34
Additional Images:
Microscopic image showing stained tissue with a large curved vessel in the center, surrounded by blue-stained cell nuclei and brown-stained structures. Microscopic image showing a blood vessel in tissue, with cell nuclei stained blue and vessel walls stained dark brown. Microscopic image of stained intestinal tissue showing glandular structures with darkly stained nuclei and lightly stained cytoplasm. Microscopic image of tissue section showing glandular structures with blue-stained nuclei and some brown-stained cells, viewed under a light microscope.
Product Code: 8277-C010: RTU, 10 capsules; 1 pack
8277-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: GM038
Host Clonality: mouse monoclonal
Control Tissue: appendix, myeloma, and plasmacytoma
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
CD38 protein is expressed on a wide range of cells with the highest expression levels typically seen in plasma cells. CD38 protein is found on immature cells of the B-cell and T-cell lineages, but is absent from most mature, resting peripheral lymphocytes.
Tissue-Tek Genie<sup>®</sup> anti-CD38
Additional Images:
Microscopic view of tissue sample showing clusters of brown-stained cells against a background of blue-stained cells, likely indicating immunohistochemical staining. Microscopic image showing clusters of densely packed brown-stained cells and lighter blue areas, likely indicating a tissue sample with specific cellular markers. Microscopic image showing tissue section with cells stained in brown and blue, indicating presence of specific proteins or cellular components. White areas represent adipose tissue. Microscopic image showing tissue section with brown-stained immune cells, blue-stained nuclei, and white adipose tissue areas on the left.
Product Code: 8226-C010: RTU, 10 capsules; 1 pack
8226-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP204
Host Clonality: rabbit monocolonal
Control Tissue: tonsil, appendix, and some T-cell lymphomas
Staining Pattern: membraneous
Regulatory Status: IVD, FDA Class I
CD4 is a transmembrane protein expressed in helper T-cells, the majority of mature peripheral T-lymphocytes and mature thymocytes, and a subset of suppressor of cytotoxic T-cells.
Tissue-Tek Genie<sup>®</sup> anti-CD4
Additional Images:
Microscopic image showing clusters of brown-stained cells among blue-stained tissue, likely representing immunohistochemical staining in a tissue sample. Microscopic view of tissue sample showing cells stained in varying shades of brown and blue for histological examination.
Product Code: 8279-C010: RTU, 10 capsules; 1 pack
8279-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: DF-T1
Host Clonality: mouse monoclonal
Control Tissue: lymph node, tonsil, appendix
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
CD43 is membrane glycoprotein expressed on the surface of thymocytes, T-cells, and cells of the myeloid lineage. The antibody labels CD43 in normal and neoplastic cells.
Tissue-Tek Genie<sup>®</sup> anti-CD43
Additional Images:
Microscopic view of densely packed cells with scattered lighter streaks and spots, likely showing a tissue sample under high magnification. Microscopic view of densely packed cells with varied staining intensity, showing an irregular distribution of lighter and darker areas across the tissue sample. Microscopic view of densely packed cells with dark blue nuclei and scattered brown-stained areas, typical of tissue stained using immunohistochemistry. Microscopic view of tissue section showing densely packed blue-stained cells with scattered brown-stained spots, likely highlighting specific cell components or markers.
Product Code: 8271-C010: RTU, 10 capsules; 1 pack
8271-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: GR009
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, liver
Staining Pattern: membraneous
Regulatory Status: IVD, FDA Class I
CD45 is a transmembrane protein which is also known as Leucocyte Common Antigen, LCA. It is expressed on most nucleated cells of hematopoietic origin and has various isoforms.
Tissue-Tek Genie<sup>®</sup> anti-CD45
Additional Images:
Microscopic image showing clusters of brown-stained cells and scattered blue nuclei on a light background, indicative of possible cellular or tissue sample analysis. Microscopic view of brain tissue showing dark brown abnormal protein deposits and scattered blue-stained cell nuclei.
Product Code: 8251-C010: RTU, 10 capsules; 1 pack
8251-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP132
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, appendix, colon
Staining Pattern: membraneous
Regulatory Status: IVD, FDA Class I
CD7 is a transmembrane protein expressed on T-lymphocytes in thymus, NK cells, peripheral lymphoid tissue and blood.
Tissue-Tek Genie<sup>®</sup> anti-CD5
Additional Images:
Microscopic image showing clusters of dark-stained cells amid lighter-stained tissue, likely representing cellular activity in a tissue sample. Microscopic image showing a tissue sample with densely packed dark-stained cells and lighter areas, typical of immunohistochemistry staining.
Product Code: 8274-C010: RTU, 10 capsules; 1 pack
8274-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: MRQ-42
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, appendix, liver
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
CD56, also known as neuronal cell adhesion molecule (NCAM), is a membrane protein expressed in neurons and glial cells of the central nervous system, nerves and neuromuscular junctions of the peripheral nervous system, most types of neuroendocrine cells, various epithelial cells, smooth muscle cells, osteoblasts, natural killer (NK) cells and NK-like T-cells.
Tissue-Tek Genie<sup>®</sup> anti-CD56
Additional Images:
Microscopic view of tissue sample stained blue with scattered darker structures and fibrous patterns, displaying cellular and structural detail. Microscopic image showing densely packed blue-stained cells with some brown-stained fibrous structures, likely from a tissue sample. Microscopic image of tissue stained for immunohistochemistry, showing dark brown-stained cells among mostly light blue cells, with a clear area on the right side. Microscopic image showing tissue with clusters of brown-stained cells among predominantly blue-stained cells and a section of white, bubble-like spaces on the right.
Product Code: 8338-C010: RTU, 10 capsules; 1 pack
8338-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: NK1
Host Clonality: mouse monoclonal
Control Tissue: lymph node and tonsil
Staining Pattern: membraneous
Regulatory Status: IVD, FDA Class I
CD57 is expressed on subtypes of T-cells, natural killer (NK) cells, and other peripheral blood mononuclear cells. CD57 is also present in glial cells, a variety of other neural and epithelial cells, as well as various neural tumors. In addition, CD57 is expressed in prostate tissue, prostate adenocarcinoma, papillary thyroid carcinomas and thymomas.
Tissue-Tek Genie<sup>®</sup> anti-CD57
Additional Images:
Microscopic view of tissue stained with immunohistochemistry, showing numerous dark brown-stained cells scattered among lighter background cells. Microscopic view of a tissue sample stained with brown and blue markers, showing scattered dark-stained cells among lighter-stained background cells. Microscope image showing tissue with a dense, dark brown linear structure near the top and lighter, irregularly shaped cells scattered throughout the field. Microscopic image showing neural tissue with dark-stained regions and clusters of cells, possibly indicating an area of pigmentation or pathological change.
Product Code: 8518-C010: RTU, 10 capsules; 1 pack
8518-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: ZM33
Host Clonality: mouse monoclonal
Control Tissue: bone marrow, AML
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
CD61 (platelet glycoprotein IIIa, GPIIIa) is expressed in platelets and megakaryocytes, as well as endothelial cells, monocytes, smooth muscle cells, some B-cells, macrophages, mast cells, osteoclasts, and fibroblasts.
Tissue-Tek Genie<sup>®</sup> anti-CD61
Additional Images:
Microscopic view of neural tissue showing scattered neurons, glial cells, and fibrous structures stained in brown and blue. Microscopic view of brain tissue stained to highlight individual cells and fibers; small, round, and elongated structures are visible against a brownish background. Microscopic image of tissue with scattered dark brown clusters and light blue round cells, likely indicating the presence of stained structures among normal cells. Microscopic image showing clusters of dark brown stained cells among numerous light purple cells, with several large white circular spaces.
Product Code: 8283-C010: RTU, 10 capsules; 1 pack
8283-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP211
Host Clonality: rabbit monoclonal
Control Tissue: pancreas, skin, prostate, melanoma
Staining Pattern: cytoplasmic (with occasional dot-like pattern) and membraneous
Regulatory Status: IVD, FDA Class I
CD63 is a 53 kD lysosomal membrane protein expressed by a broad range of tissues/cell types, including platelets, granulocytes, basophils, a subset of T-cells, endothelial cells, sweat gland, islets of Langerhans, pancreas, prostate, and melanoma.
Tissue-Tek Genie<sup>®</sup> anti-CD63
Additional Images:
Microscopic view of tissue stained with blue dye, showing cells and nuclei highlighted in various shades of blue and gray. A blue and white cell. Microscopic view of tissue section showing numerous blue-stained cell nuclei and scattered brown-stained regions. Microscopic image showing cells with blue-stained nuclei and scattered brown staining, likely indicating the presence of a specific protein via immunohistochemistry.
Product Code: 8275-C010: RTU, 10 capsules; 1 pack
8275-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: GR021
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, brain
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
CD68 is an intracellular protein expressed on macrophages, histiocytes, myeloid precursor cells in the bone marrow, and somenon-hematopoietic tissues such as Kupffer cells in liver, and cells in renal glomeruli and tubules.
Tissue-Tek Genie<sup>®</sup> anti-CD68
Additional Images:
Microscopic image showing blue-stained cell nuclei and brown pigment deposits among tubular structures, likely indicating immunohistochemical staining in tissue. Microscopic image shows tissue with oval-shaped cell clusters and scattered dark brown and blue stained cells.
Product Code: 8251-C010: RTU, 10 capsules; 1 pack
8251-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP132
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, appendix, colon
Staining Pattern: membraneous
Regulatory Status: IVD, FDA Class I
CD7 is a transmembrane protein expressed on T-lymphocytes in thymus, NK cells, peripheral lymphoid tissue and blood.
Tissue-Tek Genie<sup>®</sup> anti-CD7
Additional Images:
Microscopic image of tissue sample showing clusters of blue-stained cells surrounding white, irregularly shaped spaces on a light background. Microscopic image showing tissue with blue-stained cell nuclei and some dark brown spots, likely indicating immunohistochemical staining. White spaces separate cell clusters.
Product Code: 8322-C010: RTU, 10 capsules; 1 pack
8322-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP232
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, appendix liver, placenta, bone marrow, AML-M6
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
CD71 is regarded as a proliferation marker, and is expressed on myelocytes, activated B- and T-cells, thymocytes, macrophages, proliferating cells, as well as metabolically active cells, e.g., placental syncytiotrophoblasts, basal keratinocyte, hepatocyte, endocrine cells, and spermatocytes. CD71 expression is observed in various neoplasms.
Tissue-Tek Genie<sup>®</sup> anti-CD71
Additional Images:
Microscopic image of tissue showing clusters of cells with dark-stained nuclei and light cytoplasm, surrounded by a pale background. Microscopic view of tissue section showing clusters of cells with dark-stained nuclei and light cytoplasm, surrounded by a pale extracellular matrix. Microscopic view of tissue sample showing numerous round, dark-stained cell nuclei scattered throughout a pale background. Microscopic image showing many small, round, blue-stained cell nuclei scattered across pale tissue with a few larger, irregular white spaces.
Product Code: 8278-C010: RTU, 10 capsules; 1 pack
8278-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: GR019
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, colon, appendix
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
CD79a is a membrane protein expressed on B-cells from precursors through plasma cells. CD79a is also found to be expressed in 10% of T-lymphoblastic leukemia/lymphoma.
Tissue-Tek Genie<sup>®</sup> anti-CD79a
Additional Images:
Microscopic image showing densely packed brown-stained cells with irregular shaped lighter areas and small, round blue nuclei distributed throughout. Microscopic view of tissue section stained with brown dye, showing clusters of dark-stained cells and lighter areas representing unstained regions. Microscopic view of tissue showing circular glandular structures with brown-stained cells and light blue cell outlines, likely indicating immunohistochemistry labeling. Microscopic image showing stained cross-sections of glandular tissue, with brown-stained cells surrounding circular gland structures.
Product Code: 8252-C010: RTU, 10 capsules; 1 pack
8252-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: C8/144B
Host Clonality: mouse monoclonal
Control Tissue: normal tonsil, spleen
Staining Pattern: mainly membraneous
Regulatory Status: IVD, FDA Class I
CD8 is a transmembrane protein expressed in mature cytotoxic/suppressor T-cells.
Tissue-Tek Genie<sup>®</sup> anti-CD8
Additional Images:
Microscopic view of numerous small blue and some brown-stained cells dispersed on a light background, likely indicating an immunohistochemical stain of tissue. Microscopic image showing clusters of dark brown-stained cells scattered among numerous smaller blue-stained cells, suggesting immunohistochemical staining of tissue.
Product Code: 8285-C010: RTU, 10 capsules; 1 pack
8285-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP25
Host Clonality: rabbit monoclonal
Control Tissue: appendix, pancreas
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
CDX2 is a transcription factor essential for differentiation of epithelium in the intestine, pancreas, and biliary tract. CDX2 is expressed in epithelial cells from the duodenum to rectum, including pancreas and biliary tract.
Tissue-Tek Genie<sup>®</sup> anti-CDX2
Additional Images:
Microscopic image of a tissue section showing glandular structures with dark-stained outlines and clusters of cells on a light background. Microscopic view of tissue showing glandular structures with dark-stained cell borders and blue-stained nuclei, likely from a histological section.
Product Code: 8225-C010: RTU, 10 capsules; 1 pack
8225-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: COL-1
Host Clonality: mouse monoclonal
Control Tissue: normal colon
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
CEA (Carcinoembryonic Antigen) is a membrane protein expressed on colon and variety of other normal tissues.
Tissue-Tek Genie<sup>®</sup> anti-CEA
Additional Images:
Microscopic view of a tissue section stained with brown and blue dyes, showing cellular structures and branching patterns. Microscopic image of tissue section stained to show cellular structures, with dark brown and light blue areas highlighting different types of cells and tissue organization. Microscopic image of liver tissue showing hepatocytes, a central vein, and scattered blue-stained nuclei. A microscope view of a human tissue.
Product Code: 8286-C010: RTU, 10 capsules; 1 pack
8286-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: LK2H10
Host Clonality: mouse monoclonal
Control Tissue: colon, appendix, brain, pancreas, neuroendocrine tumors
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Chromogranin A is a secreted glycoprotein of the chromogranin/secretogranin family that is found in the secretory granules of most endocrine cells.
Tissue-Tek Genie<sup>®</sup> anti-Chromogranin A
Additional Images:
Microscopic image of tissue stained with clusters of dark brown cells among many small, round blue-stained cells. Microscopic image of tissue showing clusters of darkly stained cells against a background of smaller, lightly stained cells. Microscopic image of tissue showing oval-shaped cell structures with stained nuclei, likely a histology slide stained with hematoxylin and eosin. Microscopic view of stained tissue cells showing oval-shaped structures with clustered nuclei and blue cytoplasm.
Product Code: 8469-C010: RTU, 10 capsules; 1 pack
8469-M250: RTU, 1 cartridge, 250 tests; 1unit
Clone: EP12
Host Clonality: rabbit monoclonal
Control Tissue: tonsil
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
Cyclin D1 is a key cell cycle regulating protein expressed primarily during the G1 phase of the cell cycle.
Tissue-Tek Genie<sup>®</sup> anti-Cyclin D1
Additional Images:
Microscopic view of numerous round, blue-stained cells clustered together, dispersed across a pale background, suggestive of a biological tissue sample. Microscopic view of numerous small, round blue cells scattered densely across a light background, typical of a histological tissue sample stained for examination.
Product Code: 8300-C010: RTU, 10 capsules; 1 pack
8300-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: LL002
Host Clonality: mouse monoclonal
Control Tissue: tonsil, esophagus, prostate, and squamous cell carcinoma
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Cytokeratin 14 (CK14) is a member of the cytokeratin family that is usually found as a heterodimer with cytokeratin 5 to form the cytoskeleton of epithelial cells. CK14 is expressed in the basal cells of squamous epithelia, myoepithelial cells, and mesothelial cells.
Tissue-Tek Genie<sup>®</sup> anti-Cytokeratin 14
Additional Images:
Microscopic image of tissue showing clusters of densely packed, dark-stained cell nuclei surrounded by lighter fibrous or stromal tissue. Microscopic image showing clusters of dark-stained cell nuclei surrounded by fibrous, light-stained connective tissue.
Product Code: 8303-C010: RTU, 10 capsules; 1 pack
8303-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: A53-B/A2.26
Host Clonality: mouse monocolnal
Control Tissue: tonsil, esophagus, prostate
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Cytokeratin 19 is a cytokeratin protein expressed in wide variety of epithelium including colon, stomach, pancreas, biliary tract, liver, and breast.
Tissue-Tek Genie<sup>®</sup> anti-Cytokeratin 19
Additional Images:
Microscopic image showing a cross-section of hair follicles in human skin, with cellular details visible and stained for contrast. Microscopic image showing cross-sections of nerve fibers with stained myelin sheaths, displaying varying diameters and internal structures. Microscopic image of intestinal tissue stained to highlight goblet cells, with brown-stained cells in elongated structures and background cells stained blue. Microscopic image of intestinal tissue stained to highlight specific cell structures, showing dark brown epithelial cells and scattered blue cell nuclei.
Product Code: 8304-C010: RTU, 10 capsules; 1 pack
8304-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: Ks20.8
Host Clonality: mouse monocolonal
Control Tissue: normal colon
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Cytokeratin 20 is a cytokeratin protein expressed in mature enterocytes and goblet cells of the gastric and intestinal mucosa.
Tissue-Tek Genie<sup>®</sup> anti-Cytokeratin 20
Additional Images:
A close up of a cell. Microscopic image of tissue with brown-stained areas indicating positive immunohistochemical staining, and blue-stained areas representing cell nuclei. Microscopic image showing brown-stained tissue structures with oval shapes, likely highlighting specific cellular components against a lighter background. Microscopic image of tissue stained to show cell nuclei in blue and cell membranes or structures in brown, displaying glandular patterns.
Product Code: 8295-C010: RTU, 10 capsules; 1 pack
8295-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: D5/16B4
Host Clonality: mouse monoclonal
Control Tissue: tonsil, esophagus, prostate
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Keratins 5 and 6 (CK5/6) are high molecular weight cytokeratins that are expressed in various epithelial basal cells and mesothelial cells.
Tissue-Tek Genie<sup>®</sup> anti-Cytokeratin 5/6
Additional Images:
Microscopic view of tissue with dark-stained cell boundaries and light-stained interiors, showing glands or ducts in a histology slide. Microscopic image of stained tissue showing glandular structures with dark-stained cell outlines and lighter inner areas, likely illustrating a histological sample for medical analysis. Microscopic image of tissue showing densely packed cells with purple-stained nuclei and a central, irregular white space surrounded by more concentrated nuclei. Microscopic view of liver tissue showing a cluster of cells surrounding a bile duct, with cell nuclei stained blue and scattered throughout the sample.
Product Code: 8296-C010: RTU, 10 capsules; 1 pack
8296-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: OV-TL 12/30
Host Clonality: mouse monoclonal
Control Tissue: normal pancreas
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Cytokeratin 7 is a member of cytokeratin proteins expressed in most ductal, glandular, and transitional epithelia.
Tissue-Tek Genie<sup>®</sup> anti-Cytokeratin 7
Additional Images:
Microscopic image showing tissue stained with brown and blue markers, highlighting cellular structures and boundaries in a histological sample. Microscopic image showing tissue stained with brown and blue dyes, highlighting cell structures and boundaries in an irregular pattern. Microscopic view of tissue sample with glandular structures, stained to highlight cellular nuclei in blue and surrounding structures in lighter shades. Microscopic image of tissue showing glandular structures with cells stained in varying intensities of blue and purple.
Product Code: 8238-C010: RTU, 10 capsules; 1 pack
8238-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP17
Host Clonality: rabbit monoclonal
Control Tissue: liver, gastrointestinal tract, and known CK8 positive tumors
Staining Pattern: cytoplasmic and sometimes membraneous
Regulatory Status: IVD, FDA Class I
Cytokeratin 8 (CK8) is low molecular weight cytokeratin that is often co-expressed with cytokeratin 18. Cytokeratin 8 is expressed in simple, non-stratified epithelia, in transitional epithelium, and in the luminal/secretory cells of complex epithelia.
Tissue-Tek Genie<sup>®</sup> anti-Cytokeratin 8
Additional Images:
Microscopic view of stained liver tissue showing polygonal cells with brown-stained cytoplasm and scattered blue nuclei, highlighting cellular structure and tissue organization. Microscopic image of stained liver tissue showing polygonal cells with brown areas indicating protein expression and a central white portal tract. Microscopic image showing tissue with dark brown stained areas indicating positive immunohistochemical labeling, surrounded by lighter unstained or weakly stained cells. Microscopic image shows dark brown stained glandular structures within lighter surrounding tissue, indicating possible immunohistochemical staining of a tissue sample.
Product Code: 8307-C010: RTU, 10 capsules; 1 pack
8307-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: AE1/AE3
Host Clonality: mouse monoclonal
Control Tissue: normal liver, esophagus, lung
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Cytokeratins are a group of intermediate filament proteins expressed in cells of epithelial origin. The antibody cocktail of clones AE1 and AE3 labels both acidic and basic cytokeratins in normal and neoplastic cells.
Tissue-Tek Genie<sup>®</sup> anti-Cytokeratin Antibody Cocktail [AE1/AE3]
Additional Images:
Microscopic image of tissue section showing densely packed brown-stained cells surrounding a lighter triangular structure with dark linear features. Microscopic image showing a brown-stained tissue section with a central irregularly shaped lighter area and scattered dark spots throughout.
Product Code: 8306-C010: RTU, 10 capsules; 1 pack
8306-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: 34bE12
Host Clonality: Mouse monoclonal
Control Tissue: tonsil, esophagus, prostate
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Human high molecular weight cytokeratins (CK HMW) is a term that collectively refers to the basic cytokeratins 1 through cytokeratin 6 and the acidic cytokeratins cytokeratin 9 through cytokeratin 17. Among those, CK HMW clone 34bE12 recognizes cytokeratin 1, 5, 10, and 14. These cytokeratins are expressed in various epithelial basal cells and mesothelial cells.
Tissue-Tek Genie<sup>®</sup> anti-Cytokeratin HMW
Additional Images:
Microscopic image of liver tissue showing scattered cells and vacuoles, some areas stained darker, indicating cellular structures and possible abnormalities. Microscopic view of tissue sample with numerous small round cells, scattered dark spots, and several large white circular areas.
Product Code: 8294-C010: RTU, 10 capsules; 1 pack
8294-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: GM028
Host Clonality: mouse monoclonal
Control Tissue: tonsil, esophagus, prostate
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Cytokeratin 5 (CK5) is a high molecular weight (HMW) cytokeratin expressed in various epithelial basal cells and mesothelial cells. This antibody labels cytokeratins 5 and 6 in normal and neoplastic cells.
Tissue-Tek Genie<sup>®</sup> anti-Cytokeratin HMW (CK5)
Additional Images:
Microscopic image showing glandular structures with dark-stained borders and light interiors, surrounded by fibrous or connective tissue. Microscopic image of tissue showing glandular structures with dark-stained epithelial cell linings and surrounding lighter stroma, viewed under a microscope. Microscopic image showing clusters of dark-stained cell nuclei and several irregularly shaped empty spaces in a pale-stained tissue section. Microscopic view of tissue showing clusters of dark-stained cell nuclei and lighter areas, likely representing connective tissue and empty spaces or ducts.
Product Code: 8298-C010: RTU, 10 capsules; 1 pack
8298-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP17/DC10
Host Clonality: rabbit and mouse monoclonal
Control Tissue: liver, GI tract, esophagus, and known cytokeratin LMW (CK8/18) positive tumors
Staining Pattern: cytoplasmic and sometimes membraneous
Regulatory Status: IVD, FDA Class I
Cytokeratins 8 and 18 are often co-expressed in glandular and transitional epithelial cells in liver and intestine.
Tissue-Tek Genie<sup>®</sup> anti-Cytokeratin LMW (CK8/18) Antibody Cocktail [EP17/DC10]
Additional Images:
Microscopic view of tissue stained with brown dye, showing numerous clustered cells with dark nuclei and varying intensity of coloration throughout the sample. Microscopic image of tissue sample stained with brown pigment, showing clusters of cells with varying staining intensity and visible nuclei. Microscopic image of tissue section showing dark brown stained glandular structures at the bottom and lighter unstained areas above. Microscopic image of tissue section showing glandular structures stained brown and surrounding cells stained light blue, illustrating cellular organization and contrast.
Product Code: 8309-C010: 10 capsules, RTU; 1 pack
8309-M250: 1 cartridge, 250 tests, RTU; 1 unit
Clone: AE1/AE3/DC10
Host Clonality: antibody cocktail
Control Tissue: normal liver, esophagus, lung
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Cytokeratins is a group of intermediate filament proteins expressed in cells of epithelial origin. The antibody cocktail of clones AE1, AE3, and DC10 labels both acidic and basic cytokeratins in normal and neoplastic cells.
Tissue-Tek Genie<sup>®</sup> anti-Cytokeratin Pan Antibody Cocktail [AE1/AE3/DC10]
Additional Images:
Microscopic view of stained tissue cells with varying shades of brown and blue, showing cell nuclei and structural details. Microscopic image of tissue cells stained with brown and blue hues, showing cell nuclei and varied cellular structures.
Product Code: 8311-C010: RTU, 10 capsules; 1 pack
8311-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: GM007
Host Clonality: mouse monoclonal
Control Tissue: intestine
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Desmin is an intermediate filament of all three types of muscle cells (skeletal, cardiac, and smooth muscle). Desmin is also expressed in myofibroblasts and mesothelial cells but is absent in myoepithelial cells, malignant mesothelioma, and adenocarcinoma. Desmin is expressed in the majority of rhabdomyomas, leiomyomas, rhabdomyosarcomas, and leiomyosarcomas.
Tissue-Tek Genie<sup>®</sup> anti-Desmin
Additional Images:
Microscopic image of tissue showing dense brown staining in clustered and streaked patterns with scattered blue cell nuclei, likely indicating an immunohistochemical stain. Microscopic view of tissue sample showing densely packed dark brown stained areas with lighter regions and scattered blue nuclei, likely from immunohistochemical staining. Microscopic image showing dense clusters of dark-stained cells in the upper area and elongated, fiber-like structures in the lower area. A close up of a cell.
Product Code: 8368-C010: RTU, 10 capsules; 1 pack
8368-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: DOG1.1
Host Clonality: mouse monoclonal
Control Tissue: appendix, GIST
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
DOG1 protein is expressed predominantly on the plasma membrane of gastrointestinal interstitial cells of Cajal, acinic cells in salivary glands, pancreatic centroacinar cells, and epithelium of the biliary tract, breast, stomach, and prostate.
Tissue-Tek Genie<sup>®</sup> anti-DOG1
Additional Images:
Microscopic view of tissue with scattered dark-stained cell nuclei and a pale, fibrous background, typical of histological slides used in pathology. Microscopic view of tissue sample with scattered pale blue and purple stained cells on a light background.
Product Code: 8229-C010: RTU, 10 capsules; 1 pack
8229-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: GM016
Host Clonality: mouse monoclonal
Control Tissue: appendix, liver, ductal breast carcinoma
Staining Pattern: membraneous
Regulatory Status: IVD, FDA Class I
E-cadherin is a transmembrane cell adhesion glycoprotein that is critical for epithelial junction formation. E-cadherin is expressed in a majority epithelial cells.
Tissue-Tek Genie<sup>®</sup> anti-E-Cadherin
Additional Images:
Microscopic image of liver tissue showing a large pale cell with several dark spots surrounded by many smaller, densely packed cells. Microscopic view of stained tissue showing a large pale cell with a prominent nucleus among many smaller, densely packed cells. Microscopic image showing a tissue sample with brown-stained cells along a structure, indicating positive immunohistochemical staining against a mostly light blue background. Microscopic image of tissue with scattered blue-stained nuclei and a cluster of dark brown-stained cells along a linear structure, indicating possible immunohistochemical staining.
Product Code: 8230-C010: RTU, 10 capsules; 1 pack
8230-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: VU-1D9
Host Clonality: mouse monoclonal
Control Tissue: normal colon
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
Epithelial Cell Adhesion Molecule is a membrane protein expressed on epithelial cells.
Tissue-Tek Genie<sup>®</sup> anti-Epithelial Cell Adhesion Molecule
Additional Images:
Microscopic image showing densely packed cells with darkly stained nuclei in the upper half and lighter staining with fewer cells in the lower half. Microscopic image showing tissue sample with densely packed, stained cells in the upper area and fewer, lighter-stained cells in the lower area. Microscopic image showing tissue stained brown on the left and lower areas, with blue-stained cells scattered throughout the lighter upper and right regions. Histological image showing brown-stained cells concentrated in certain areas, while other regions contain mostly unstained or faintly stained cells with visible nuclei.
Product Code: 8233-C010: RTU, 10 capsules; 1 pack
8233-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: E29
Host Clonality: mouse monoclonal
Control Tissue: breast ductal carcinoma
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
Epithelial Membrane Antigen is a membrane protein expressed on the apical surface of secretory glandular epithelial cells in a variety of tissues.
Tissue-Tek Genie<sup>®</sup> anti-Epithelial Membrane Antigen
Additional Images:
Microscopic image of stained tissue sample showing clusters of cells with dark brown and light blue coloration, likely from immunohistochemistry analysis. Microscopic image of tissue stained with brown and blue dyes, showing clustered cells and irregular structures, commonly seen in histopathology slides. Microscopic image showing dense clusters of blue-stained cells with a dark brown irregular region at the top right, indicating a possible stained tissue structure. Microscopic image showing brown-stained neural tissue adjacent to densely packed blue-stained cells, likely representing an immunohistochemical analysis of a tissue section.
Product Code: 8323-C010: RTU, 10 capsules; 1 pack
8323-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP111
Host Clonality: rabbit monoclonal
Control Tissue: appendix, tonsil, ERG positive prostate carcinoma
Staining Pattern: nucrear
Regulatory Status: IVD, FDA Class I
Erythroblast transformation-specific transcription factor (ERG) is expressed in endothelial cells of blood and lymphatic vessels, and bone marrow stem cells. In particular, the TMPRSS2-ERG fusion gene is found in
45-65% of prostate cancers. ERG is expressed in endothelial neoplasms including hemangioendothelioma, angiosarcoma and Kaposi sarcoma. Clone EP111 is also named as EPR3864. This clone is capable of detecting both wild-type and truncated ERG.
Tissue-Tek Genie<sup>®</sup> anti-ERG
Additional Images:
Microscopic image of tissue section stained to reveal cellular and structural details, showing densely packed cells and varying coloration. Microscopic image of tissue sample showing densely packed cells, with varying shades of brown and blue indicating possible staining for histological analysis. Microscopic view of tissue sections with blue-stained cells and scattered brown nuclei, indicating immunohistochemical staining. Microscopic image of tissue stained with immunohistochemistry, showing brown-stained cell nuclei distributed among blue-stained epithelial cells.
Product Code: 8293-C010: RTU, 10 capsules; 1 pack
8293-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP292
Host Clonality: rabbit monoclonal
Control Tissue: skin, gastrointestinal tract, liver, dermatofibroma
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Factor XIIIa protein is a blood and intracellularly produced coagulation factor, which is widely expressed in a variety of cell types, including dermal dendrocytes in skin.
Tissue-Tek Genie<sup>®</sup> anti-Factor XIIIa
Additional Images:
Microscopic image showing elongated blue-stained nuclei scattered within a pale, fibrous tissue background, typical of a histology slide. Microscopic image showing spindle-shaped cells stained blue, arranged in interlacing bundles within a fibrous tissue matrix.
Product Code: 8314-C010: RTU, 10 capsules; 1 pack
8314-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: polyclonal
Host Clonality: rabbit polyclonal
Control Tissue: stomach, gastrin-secreting neuroendocrine tumor
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class i
Gastrin protein is a peptide hormone that stimulates production gastric acid by the parietal cells of the stomach, and also aids in gastric motility. Gastrin is produced by G-cells in the pyloric antrum of stomach.
Tissue-Tek Genie<sup>®</sup> anti-Gastrin
Additional Images:
Microscopic image showing clusters of stained cells with varying density and distribution across the tissue sample. Microscopic image shows a tissue section stained with hematoxylin; various cell nuclei are visible as dark blue or purple dots across the sample.
Product Code: 8357-C010: RTU, 10 capsules; 1 pack
8357-M250: RTU, 250 tests, 1 cartridge; 1
Clone: QR018
Host Clonality: rabbit monoclonal
Control Tissue: cervix, tonsil, kidney, selective breast and urothelial carcinoma
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I

GATA binding protein 3 (GATA3) is a transcription factor that plays a crucial role in the development and differentiation of various tissues.

Tissue-Tek Genie<sup>®</sup> anti-GATA3
Additional Images:
Microscopic view of tissue sample stained to highlight specific cellular structures; round blue shapes indicate cell nuclei, and brown areas show marked features. Microscopic view of tissue with numerous small, round, blue-purple stained cells and several brown-stained structures scattered throughout the field. Microscopic image showing clusters of dark-stained cell nuclei within a fibrous, light-stained tissue background. Microscopic view of tissue sample showing numerous light blue cells and scattered dark brown-stained nuclei, indicating areas of possible immunohistochemical staining. Microscopic image showing tissue with numerous dark brown-stained cell nuclei scattered throughout a lighter background, indicating areas of cellular activity or marker expression.
Product Code: 8325-C010: RTU, 10 capsules; 1 pack
8325-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP95
Host Clonality: rabbit monoclonal
Control Tissue: skin, GCDFP-15 positive breast and breast carsinoma
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Gross cystic disease fluid protein-15 (GCDFP-15) is a secretory glycoprotein and is expressed in the acinic cells of the breast, salivary glands, sweat glands, and seminal vesicle. GCDFP-15 is often expressed in neoplastic cells of breast carcinomas (50-70%), mammary and extramammary Paget’s disease, sweat gland tumors (particularly apocrine), and salivary gland tumors.
Tissue-Tek Genie<sup>®</sup> anti-GCDFP-15
Additional Images:
Microscopic image shows a tissue sample with round, white adipocyte cells and darker stained cell nuclei scattered throughout the background. Microscopic image of tissue with numerous round, dark-stained cell nuclei and several large, white adipocyte-like cells dispersed throughout the sample. Microscopic view of a tissue section showing oval-shaped glandular structures with dark-stained cell nuclei and lighter-stained cytoplasm. Microscopic view of a tissue section showing oval-shaped glandular structures with densely packed dark-stained nuclei and lighter cytoplasmic areas.
Product Code: 8316-C010: RTU, 10 capsules; 1 pack
8316-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: GA-5
Host Clonality: mouse monoclonal
Control Tissue: brain, ganglia of appendix/GI tract, and astrocytoma
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
GFAP is specifically expressed in astrocytes and ependymal cells. It is also expressed in Schwann cells and satellite cells in sensory ganglia of the peripheral nervous system, and in myoepithelial cells and chondroblasts. Immature oligodendrocytes and choroid plexus cells may be GFAP positive. Astrocytoma, ependymoma, glioblastoma, and oligodendroglioma are almost always GFAP positive.
Tissue-Tek Genie<sup>®</sup> anti-Glial Fibrillary Acidic Protein (GFAP)
Additional Images:
Microscopic image showing clusters of blue-stained cells with irregular shapes and scattered brown-stained structures within a tissue sample. Microscopic image of tissue showing scattered dark-stained cells and structures among lighter blue and grey cellular areas, indicative of immunohistochemical staining. Microscopic image shows a tissue section with many small, blue-stained cell nuclei dispersed throughout a pale background. Microscopic view of tissue section showing numerous small, evenly distributed blue-stained cell nuclei on a pale background.
Product Code: 8234-C010: RTU, 10 capsules; 1 pack
8234-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP230
Host Clonality: rabbit monoclonal
Control Tissue: spleen, tonsil, selected T-cell lymphomas
Staining Pattern: cytoplasmic, granular
Regulatory Status: IVD, FDA Class I
Granzyme B is a serine protease expressed by cytotoxic T-lymphocytes and natural killer cells. It induces apoptosis in target cells of these lymphocytes.
Tissue-Tek Genie<sup>®</sup> anti-Granzyme B
Additional Images:
Microscopic image showing numerous blue-stained nuclei of cells scattered across a light background, likely from a tissue sample stained with hematoxylin. Microscopic image of stained cells, showing numerous round blue nuclei scattered throughout a pale background. Microscopic view of densely packed blue and purple stained cells, likely showing human or animal tissue sample under high magnification. Microscopic view of densely packed blue-stained cells, likely indicating lymphoid tissue or a cellular sample under high magnification.
Product Code: 8317-C010: RTU, 10 capsules; 1 pack
8317-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP179
Host Clonality: rabbit monoclonal
Control Tissue: H. pylori infected stomach
Staining Pattern: cell wall of H. pylori within the crypts of the stomach mucosa
Regulatory Status: IVD, FDA Class I
H. pylori are spiral-curved, gram-negative bacteria that are known to cause peptic and duodenal ulcers and chronic gastritis in humans. H. pylori may also be involved in the development of adenocarcinoma and low grade lymphoma of mucosa associated lymphoid tissue in stomach.
Tissue-Tek Genie<sup>®</sup> anti-Helicobacter pylori
Additional Images:
Microscopic image of tissue section stained blue and brown, showing dense clusters of cells with varying shapes and scattered darker regions. Microscopic image of tissue section stained with blue and brown dyes, showing clusters of cells and varying structural patterns.
Product Code: 8374-C010: RTU, 10 capsules; 1 pack
8374-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: OCH1E5
Host Clonality: mouse monoclonal
Control Tissue: liver, HCC
Staining Pattern: granular cytoplasmic
Regulatory Status: IVD, FDA Class I
Hepatocyte Specific Antigen, also known as Hepatocyte Paraffin 1 (Hep Par 1), is expressed in normal and neoplastic hepatocytes. Hep Par 1 is a highly specific marker for HCC, although several non-hepatic tumors occasionally can show some Hep Par 1 positivity.
Tissue-Tek Genie<sup>®</sup> anti-Hepatocyte Specific Antigen (HEP PAR 1)
Additional Images:
Microscopic view of tissue sample showing scattered brown-stained cells among mostly blue-stained cells, indicating immunohistochemical staining results. Microscopic image showing numerous small, dark brown-stained cells scattered among larger pale cells, indicating immunohistochemical staining within tissue. Microscopic view of pancreatic tissue showing clusters of cells with dark purple-stained nuclei dispersed throughout a lighter background. Microscopic image showing clusters of pancreatic islet cells with dark-stained nuclei among lighter-stained surrounding tissue.
Product Code: 8378-C010: RTU, 10 capsules; 1 pack
8378-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: 13B10
Host Clonality: mouse monoclonal
Control Tissue: neoplastic cells of KS
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
Human herpesvirus type 8, also known as KS-associated herpesvirus, causes KS as well as primary effusion lymphoma and some types of multi-centric CD. Latent nuclear antigen protein is consistently expressed in HHV8 infected cells.
Tissue-Tek Genie<sup>®</sup> anti-HHV8
Additional Images:
Microscopic view of densely packed blue-stained cells, possibly a tissue sample, showing varied cell distribution and structure. Microscopic view of densely packed blue-stained cells clustered together, possibly illustrating tissue or cell samples under a microscope.
Product Code: 8229-C010: RTU, 10 capsules; 1 pack
8229-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP170
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, lymph node, a subset of B-cell neoplasms
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
In normal, healthy serum IgA is generally the second most abundant of the Ig heavy chain classes. Igs are produced in mature B-cells and plasma cells, and the amount and type of Ig heavy chain classes can vary in different stages of B-cell maturation: Igs in the earlier stages of maturation are present in the cytoplasm, whereas Igs on the membrane surface are more characteristic of mature B-cells in the mantle zone. Benign populations of B-cells show a mix of light chain classes with varying antigen specificities, while B-cell derived neoplasms, such as B-cell lymphoma, and plasma cell neoplasms, often produce only one type of clonal Ig light chain.
Tissue-Tek Genie<sup>®</sup> anti-IgA
Additional Images:
Microscopic image of tissue stained with hematoxylin and DAB, showing densely packed blue and brown-stained cells with some fibrous structures on the left side. Microscopic image showing densely packed blue-stained cells with scattered brown areas and a fibrous structure on the left side. Microscopic image showing many small, round, blue-stained cell nuclei scattered throughout tissue with a few darker brown-stained spots. Microscopic image of tissue section showing numerous round blue-stained cell nuclei and scattered brown-stained cells on a light background.
Product Code: 8382-C010: RTU, 10 capsules; 1 pack
8382-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP173
Host Clonality: rabbit monoclonal
Control Tissue: tonsil or lymph nodes or selected B-cell neoplasms
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
In normal, healthy serum, IgD is generally the fourth most abundant of the immunoglobulin heavy-chain classes. Immunoglobulin (Igs) are produced in mature B-cells and plasma cells, and the amount and type of Ig can vary in different stages of B-cell maturation: Igs in the earlier stages of maturation are present in the cytoplasm, whereas surface expression of Igs is more characteristic of mature B-cells in the mantle zone.
Tissue-Tek Genie<sup>®</sup> anti-IgD
Additional Images:
Microscopic view of brain tissue showing scattered cell nuclei stained dark blue and pale background with fibrous structures. Microscopic view of brain tissue showing numerous small, round cells with dark nuclei scattered across a pale background.
Product Code: 8383-C010: RTU, 10 capsules; 1 pack
8383-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: RM116
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, lymph node or selected B-cell neoplasms
Regulatory Status: IVD, FDA Class I
In normal healthy serum, IgG is the most abundant of the Ig classes. Igs are produced in mature B-cells and plasma cells, and the amount and type of Ig can vary in different stages of B-cell maturation: in the earlier stages of maturation, Igs are present in the cytoplasm, whereas surface expression of Igs is more characteristic of mature B-cells in the mantle zone.
Tissue-Tek Genie<sup>®</sup> anti-IgG
Additional Images:
Microscopic image of brain tissue showing scattered blue-stained cells and a few brownish deposits against a light background. Microscopic image showing scattered blue-stained cell nuclei and a few irregular brown deposits on a pale background.
Product Code: 8384-C010: RTU, 10 capsules; 1 pack
8384-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: HP6025
Host Clonality: mouse monoclonal
Control Tissue: tonsil, parotid gland, IgG4 related sclerosing pancreatitis
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Immunoglobulin (Ig) consists of two identical heavy chains (γ, or μ, or α, or δ, or ε) and two identical light chains (kappa or lambda). IgG is the most abundant immunoglobulin and has several subclasses (IgG1, 2, 3, and 4). IgG4-related sclerosing disease (IgG-RD) is a fibroinflammatory and a multi-system disorder characterized by elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells.
Tissue-Tek Genie<sup>®</sup> anti-IgG4
Additional Images:
Microscopic view of tissue stained with hematoxylin and eosin, showing densely packed blue-stained nuclei and several larger, irregularly shaped cells. Microscopic image of tissue stained with hematoxylin and eosin, showing densely packed blue nuclei and some lighter cytoplasmic areas with a few dark brown spots. Microscopic image of pancreatic tissue showing an islet of Langerhans surrounded by exocrine cells, with cell nuclei stained dark blue. Microscopic image of pancreatic tissue showing a lighter-stained islet of Langerhans surrounded by darker-stained exocrine cells; cell nuclei are visible as dark dots.
Product Code: 8385-C010: RTU, 10 capsules; 1 pack
8385-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: polyclonal
Host Clonality: rabbit polyclonal
Control Tissue: tonsil, lymph node, or selected B-cell neoplasms
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
In normal, healthy serum IgM is generally the third most abundant of the immunoglobulin heavy-chain classes. Immunoglobulin (Igs) are produced in mature B-cells and plasma cells, and the amount and type of Ig can vary in different stages of B-cell maturation: Igs in the earlier stages of maturation are present in the cytoplasm, whereas surface expression is more characteristic of mature B-cells in the mantle zone.
Tissue-Tek Genie<sup>®</sup> anti-IgM
Additional Images:
Microscopic view of a tissue section stained to highlight cell nuclei in blue and certain structures in brown, showing layered cellular organization. Microscopic image of a tissue section stained to highlight cell nuclei and structural features; nuclei appear as dark blue dots throughout the sample. Microscopic image of tissue section stained to show cell nuclei in blue and other cellular components in brown; clusters of cells are visible throughout the sample. Microscopic view of stained pancreatic tissue showing islet cells and scattered nuclei, with light and dark areas indicating cellular structures.
Product Code: 8394-C010: RTU, 10 capsules; 1 pack
8394-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: polyclonal
Host Clonality: rabbit polyclonal
Control Tissue: tonsil, lymph node, and kappa light chain protein positive B-cell neoplasms
Staining Pattern: membraneous and cytoplsmic
Regulatory Status: IVD, FDA Class I
Amounts and types of immunoglobulin (Ig) monomers can vary in different stages of B-cell maturation. Igs are expressed in the cytoplasm (early stage of maturation, plasma cells) or on the membrane (B-cells in the mantle zone). Neoplasms such as B-cell lymphoma and plasma cell myeloma may be demonstrated to be clonal when they produce only one type of Ig light chain.
Tissue-Tek Genie<sup>®</sup> anti-Kappa Light Chains
Additional Images:
Microscopic view of tissue stained in shades of blue and purple, with scattered dark clusters and spots visible throughout the sample. Microscopic image showing a dense field of blue-stained cells with scattered dark brown spots on a speckled background.
Product Code: 8473-C010 10 capsules, RTU; 1 pack
8473-M250 1 cartridge, 250 tests, RTU; 1 unit
Clone: GM010
Host Clonality: mouse monoclonal
Control Tissue: normal tonsil
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
Ki67 is a proliferation-associated nuclear protein expressed during all active phases of the cell cycle and is absent in resting cells.
Tissue-Tek Genie<sup>®</sup> anti-Ki67
Additional Images:
Microscopic image of tissue stained to show cell nuclei in blue and proliferating cells in brown, highlighting cellular activity and structure. Microscopic image of tissue sample showing clusters of cells with darkly stained nuclei scattered throughout a lighter background.
Product Code: 8398-C010: RTU, 10 capsules; 1 pack
8398-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: polyclonal
Host Clonality: rabbit polyclonal
Control Tissue: tonsil, lymph node, and lambda light chain protein positive B-cell neoplasms
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
Amounts and types of immunoglobulin (Ig) monomers can vary in different stages of B-cell maturation. Igs are expressed in the cytoplasm (early stage of maturation, plasma cells) or membrane (B-cells in the mantle zone). Neoplasms such as B-cell lymphoma and plasma cell myeloma may be demonstrated to be clonal when they produce only one type of Ig light chain.
Tissue-Tek Genie<sup>®</sup> anti-Lambda Light Chains
Additional Images:
Microscopic image showing densely packed cells with dark brown staining and blue nuclei, possibly indicative of immunohistochemical staining in tissue. Microscopic view of densely packed cells stained brown and blue, showing a granular texture across the image.
Product Code: 8333-C010: RTU, 10 capsules; 1 pack
8333-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: polyclonal
Host Clonality: rabbit polyclonal
Control Tissue: tonsil, appendix
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Lysozyme is a ubiquitous enzyme found in tears, saliva, human milk, mucus, gastrointestinal secretions, urine, serum, spleen, lung, and kidney. Lysozyme immunoreactivity is found in cytoplasmic granules of the macrophages, the granulocytes (polymorphonuclear neutrophils), reactive histiocytes, myeloid cells, and some epithelial cells.
Tissue-Tek Genie<sup>®</sup> anti-Lysozyme
Additional Images:
Microscopic image showing stained tissue with brown coloration highlighting specific cellular structures within a layered arrangement. Microscopic image of tissue section showing cells stained brown, indicating areas of protein expression, with lighter unstained areas visible. Microscopic view of stained tissue displaying elongated, layered cellular structures with dark brown and blue areas, likely indicating different cell types or staining reactions. Microscopic image of intestinal tissue showing elongated villi structures with cells stained in varying shades of blue and brown.
Product Code: 8240-C010: RTU, 10 capsules; 1 pack
8240-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP249
Host Clonality: rabbit monoclonal
Control Tissue: mammaglobin positive normal breast, breast carcinoma, skin
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Low level of expression of mammaglobin is seen in normal breast. Its expression is markedly increased in breast carcinoma and is directly correlated with a higher grade. Mammaglobin is positive in about 80% of breast carcinomas, and is more frequently expressed than GCDFP-15.
Tissue-Tek Genie<sup>®</sup> anti-Mammaglobin
Additional Images:
Microscopic view of tissue with numerous dark-stained cell nuclei dispersed throughout a fibrous, light background. Microscopic view of tissue showing numerous dark-stained cells scattered within a fibrous matrix, possibly from a histological or pathology slide. Microscopic image of kidney tissue showing glomerulus in the center and surrounding renal tubules with scattered cell nuclei stained blue. Microscopic view of kidney tissue showing a glomerulus surrounded by numerous small, round cell nuclei distributed throughout the tissue.
Product Code: 8319-C010: RTU, 10 capsules; 1 pack
8319-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP43
Host Clonality: rabbit monoclonal
Control Tissue: melanoma
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Melan-A, also known as Melanoma Antigen Recognized by T-cell 1 (MART-1), is a transmembrane protein expressed in skin, melanocytes, and steroid producing cells. Melan-A is detected in melanomas and angio-myolipomas.
Tissue-Tek Genie<sup>®</sup> anti-Melan-A
Additional Images:
Histological section of human skin tissue showing layered epidermis and underlying dermis with scattered dark-stained cells. Microscopic image of a tissue section showing multiple layers of cells with dark-stained nuclei and scattered brown-stained immune cells in the lower region.
Product Code: 8371-C010: RTU, 10 capsules; 1 pack
8371-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: HMB45/EP43/T311
Host Clonality: mouse and rabbit monoclonal
Control Tissue: skin, melanoma, adrenal gland
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
PMEL17, MART-1 and tyrosinase are proteins expressed in normal melanocytes, and are often detected in melanomas.
Tissue-Tek Genie<sup>®</sup> anti-Melanoma Pan Antibody Cocktail [HMB45/EP43/T311]
Additional Images:
Microscope image shows liver tissue with scattered cells, visible nuclei, and some areas stained pink and purple, indicating variation in cell structure and composition. Microscopic view of tissue with scattered cells, visible nuclei stained in blue, and cytoplasmic areas with varying shades of pink and white spaces between cells.
Product Code: 8232-C010: RTU, 10 capsules; 1 pack
8232-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: HMB45
Host Clonality: mouse monoclonal
Control Tissue: melanosome
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
The antibody labels melanosome protein in the cytoplasm of activated and neoplastic melanocytes. Intradermal nevi and normal resting adult melanocytes are negative.
Tissue-Tek Genie<sup>®</sup> anti-Melanosome
Additional Images:
Microscopic image showing a section of epithelial tissue with densely packed nuclei in the upper layer and loosely arranged connective tissue below. Microscopic image of human tissue stained to show cell nuclei in blue, with distinct layers and varying cell density between the upper and lower regions.
Product Code: 8324-C010: RTU, 10 capsules; 1 pack
8324-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: GM011
Host Clonality: mouse monoclonal
Control Tissue: normal colon
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
MLH1 is expressed in normal proliferating cells and, when hetero-dimerized with PMS2 (Postmeiotic segregation increased 2), is involved in repairing DNA mutations which may occur during DNA replication. Lost expression or low levels of MLH1 are associated with colorectal and other cancers.
Tissue-Tek Genie<sup>®</sup> anti-MLH1
Additional Images:
Microscopic view of tissue sample stained with dark brown and light areas, showing cellular and structural patterns. Microscopic image showing densely packed, dark-stained cells forming irregular glandular patterns, typical of tissue sample analysis in histology. Microscopic image of tissue sample showing elongated glandular structures with dark-stained nuclei and light cytoplasm, likely viewed under high magnification. Microscopic image of tissue showing elongated, oval-shaped glandular structures with blue and brown staining, surrounded by a fibrous matrix.
Product Code: 8327-C010: RTU, 10 capsules; 1 pack
8327-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: RED2
Host Clonality: rabbit monoclonal
Control Tissue: normal colon, appendix, tonsil
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
MSH2 is expressed in normal proliferating cells and, when heterodimerized with MSH6 (MutS homolog 6), is involved in repairing DNA mutations which may occur during DNA replication.
Tissue-Tek Genie<sup>®</sup> anti-MSH2
Additional Images:
Microscopic image showing densely packed dark-stained cell nuclei within tissue, likely from a histological or pathological sample for medical analysis. Microscopic view of tissue sample showing densely packed dark-stained cell nuclei and lighter background, commonly seen in histological or pathological analysis. Microscopic image showing glandular tissue cells stained blue and surrounded by numerous small dark brown nuclei. Microscope image of tissue section showing blue-stained glandular structures with scattered dark-stained nuclei throughout the surrounding area.
Product Code: 8375-C010: RTU, 10 capsules; 1 pack
8375-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: ZM32
Host Clonality: mouse monoclonal
Control Tissue: tonsil, appendix, pancreas, breast, lung
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
Mucin 1 (MUC1) is a cell surface mucin glycoprotein and is expressed on the apical borders of most glandular epithelial cells, ductal epithelial cells, and some hematopoietic cell lineages. In neoplastic tissues, MUC1 may be expressed on the entire cell surface (depolarized expression). MUC1 is overexpressed in many human cancers, including non-small cell lung carcinoma (NSCLC) and breast carcinoma.
Tissue-Tek Genie<sup>®</sup> anti-MUC1
Additional Images:
Microscopic view of stained tissue showing pigment distribution and cell nuclei, with a brown layer on the left and densely packed blue-stained cells on the right. Microscopic image showing a cross-section of tissue with brown-stained elongated cells and blue nuclei, highlighting cellular structure and organization. Microscopic view of liver tissue showing a bile duct and surrounding hepatocytes with blue-stained nuclei and light cytoplasm. Microscopic view of liver tissue showing a bile duct and surrounding hepatocytes, with cell nuclei stained blue.
Product Code: 8329-C010: RTU, 10 capsules; 1 pack
8329-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP190
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, appendix, B-cell lymphoma, and myeloma
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
Multiple Myeloma Oncogene 1 (MUM1) protein is expressed at the later stages of B-cell development and can be demonstrated in B-cells in the light zone of lymphoid germinal centers, plasma cells, a subpopulation of activated T-cells, and some melanocytes. MUM1 protein is expressed in many B-cell lymphomas, myelomas, and some melanocytic tumors.
Tissue-Tek Genie<sup>®</sup> anti-MUM-1
Additional Images:
Microscopic image of tissue stained to show brown-stained immune cells clustered within a lighter background, indicating cell distribution within the sample. Microscopic image of tissue with numerous dark brown-stained cells scattered throughout a lighter background, indicative of an immunohistochemistry stain. Microscopic image showing densely packed blue-stained cells with some lighter and darker areas, suggestive of a tissue sample stained for cellular analysis. Microscopic view of tissue stained blue and purple, showing numerous round cells with dark nuclei scattered throughout the field.
Product Code: 8407-C010: RTU, 10 capsules; 1 pack
8407-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP151
Host Clonality: rabbit monoclonal
Control Tissue: bone marrow, tonsil, liver, and myeloid leukemias
Staining Pattern: granular cytoplasmic
Regulatory Status: IVD, FDA Class I
Myeloperoxidase (MPO) is a peroxidase enzyme involved in antimicrobial activity. MPO is synthesized and expressed in precursor and mature granulocytes, including neutrophils and eosinophils, and is variably expressed in monocytes/macrophages.
Tissue-Tek Genie<sup>®</sup> anti-Myeloperoxidase (MPO)
Additional Images:
Microscopic view of densely packed blue-stained cells arranged in a uniform pattern, likely representing tissue or cell sample under high magnification. Microscopic view of numerous densely packed blue-stained cells, likely showing a tissue sample or cell culture under high magnification. Microscopic view of stained brain tissue showing numerous small, round cell nuclei and scattered dark brown deposits. Microscopic view of brain tissue showing numerous cell nuclei stained blue and several irregular dark brown deposits scattered throughout the sample.
Product Code: 8517-C010: RTU, 10 capsules; 1 pack
8517-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: SMMS-1
Host Clonality: mouse monoclonal
Control Tissue: breast, tonsil, appendix
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Myosin is one of the major contractile proteins in muscle and non-muscle cells. A Myosin molecule consists of two heavy chains (MHCs) and two pairs of light chains. MHCs have multiple isoforms. This antibody reacts with the smooth muscle myosin heavy chain, which is encoded by the MYH11 gene. Smooth muscle myosin heavy chain is expressed in visceral and vascular smooth muscle cells as well as myoepithelial cells.
Tissue-Tek Genie<sup>®</sup> anti-Myosin Smooth Muscle
Additional Images:
Microscopic view of tissue stained for immunohistochemistry, showing brown-stained areas indicating protein expression among elongated glandular structures. Microscopic image of tissue sections stained with brown, highlighting certain structures, and blue, marking cell nuclei. Microscopic view of tissue section showing numerous cells with dark blue stained nuclei and pale cytoplasm, some fibrous structures, and a small blood vessel on the left side. Microscopic image of tissue section showing numerous oval-shaped cells with blue-stained nuclei and lightly stained cytoplasm, likely from a histology slide.
Product Code: 8331-C010: RTU, 10 capsules; 1 pack
8331-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP205
Host Clonality: rabbit monoclonal
Control Tissue: lung, kidney, and known napsin A positive lung adenocarcinoma
Staining Pattern: granular cytoplasmic
Regulatory Status: IVD, FDA Class I
Napsin A is a protease that is predominantly expressed in the lung and kidney. Napsin A is expressed in alveolar type II pneumocytes in lung and proximal tubules in kidney.
Tissue-Tek Genie<sup>®</sup> anti-Napsin A
Additional Images:
Microscopic image of tissue showing brown-stained cells among lighter areas, indicating regions with higher expression of a specific marker in a histological sample. Microscopic view of tissue showing brown-stained areas interspersed with lighter regions, indicative of an immunohistochemistry analysis. Microscopic image of human colon tissue showing glandular structures, adipose tissue, and nuclei stained blue. Microscopic image of tissue showing glandular structures, connective tissue, and clusters of white adipose cells, with blue and purple staining highlighting cellular details.
Product Code: 8289-C010: RTU, 10 capsules; 1 pack
8289-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: 2F11
Host Clonality: mouse monoclonal
Control Tissue: appendix, colon, and tumors with neuronal differentation
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Neurofilaments are cytoskeletal proteins normally found in neurons and axonal processes, and often found in tumors of neural, neuroendocrine, and endocrine origin, including neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, paragangliomas, adrenal and extra-adrenal pheochromocytomas, and Merkel cell carcinoma.
Tissue-Tek Genie<sup>®</sup> anti-Neurofilament
Additional Images:
Microscopic image showing densely packed cells with varying shades of blue and brown, indicative of a stained tissue sample. Microscopic view of stained tissue showing densely packed cells, some with dark brown staining, indicating positive immunohistochemical reaction among mostly blue-stained cells. Microscopic view of a tissue section showing layered cells with stained nuclei, possibly skin epithelium; some green stains are visible at the edge of the sample. Microscopic image of human skin tissue section stained in blue and purple, showing layered epidermis and dermis, with green areas at the upper edge.
Product Code: 8447-C010: RTU, 10 capsules; 1 pack
8447-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP319
Host Clonality: rabbit monoclonal
Control Tissue: appendix, colon, pancreas, and tumors derived from neuron and endocrine
Staining Pattern: cytoplasmic and nuclear
Regulatory Status: IVD, FDA Class I
Neuron-specific enolase (NSE) is a gamma subunit homodimer and is the dominant form of the enolase isoenzymes found in neuronal and neuroendocrine cells.
Tissue-Tek Genie<sup>®</sup> anti-Neuron Specific Enolase
Additional Images:
Microscopic image of tissue section showing densely packed cells with a brown-stained irregular area in the lower left, indicating possible localization of a specific marker. Microscopic view of tissue with densely packed blue-stained cells and a distinct brown-stained area in the lower center, indicating possible abnormality or staining reaction.
Product Code: 8320-C010: RTU, 10 capsules; 1 pack
8320-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP356
Host Clonality: rabbit monoclonal
Control Tissue: prostate, testis
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
NKX3.1 protein down regulates growth of epithelial cells in prostate tissue and plays a critical role in suppressing prostate carcinoma. NKX3.1 is expressed predominantly in prostate epithelium and is also found in testis, ureter, pulmonary bronchial mucous glands, salivary gland, and some cases of ductal and lobular breast carcinoma. NKX3.1 is a highly sensitive and specific marker for prostate adenocarcinoma.
Tissue-Tek Genie<sup>®</sup> anti-NKX3.1
Additional Images:
Microscopic image of human colon tissue shows glandular structures and cells stained in varying shades of blue. Microscopic image of intestinal tissue showing multiple circular and oval-shaped crypts, with cell nuclei stained blue. Microscopic image of several round cells, some with dark-stained nuclei, showing cell structures and variations in nuclear staining within tissue sections. Microscopic image of cross-sectioned seminiferous tubules showing numerous cells, some with darkly stained nuclei, within a pale-stained background.
Product Code: 8334-C010: RTU, 10 capsules; 1 pack
8334-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP284
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, B-cell lymphoma
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
OCT.2 is a transcription factor that binds to the immunoglobulin gene and interacts with BOB.1. It is essential for expression of B-cell specific genes. OCT.2 is expressed in mature B-cells, predominantly germinal center B-cells. High levels of OCT.2 expression are also found in monocytoid B-cells and plasma cells. Various B-cell lymphomas are also positive for this marker.
Tissue-Tek Genie<sup>®</sup> anti-OCT.2
Additional Images:
Microscopic image showing densely packed dark brown cells within a lighter background, likely representing stained tissue in a biological sample. Microscopic image showing numerous dark-stained cells clustered together within a lighter background, likely representing lymphoid tissue or a similar cellular structure. Microscopic view of cells stained with varying intensities, showing clusters of dark brown and light blue cell nuclei against a white background. Microscopic view of stained cells, with densely packed blue nuclei and several dark brown spots indicating positive immunohistochemical staining.
Product Code: 8373-C010: RTU, 10 capsules; 1 pack
8373-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP66
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, liver and neoplastic breast epithelial cells of lobular type (showing loss of membrane reactivity)
Staining Pattern: membraneous staining of normal cells, membraneous and cytoplasmic staining of some neoplastic cells
Regulatory Status: IVD, FDA Class I
p120 catenin binds E-Cadherin at a juxta-membrane site while alpha-catenin and beta-catenin bind to the intracellular domain of E-Cadherin. A deficiency of E-Cadherin results in the intracytoplasmic accumulation of p120 catenin. Diffuse cytoplasmic p120 catenin staining (without strong membraneous staining) is seen in in situ and invasive lobular carcinoma and other lesions with dysfunctional E-cadherin / catenin tight junctions.
Tissue-Tek Genie<sup>®</sup> anti-p120
Additional Images:
Microscopic view of tissue with numerous circular cells, blue-stained nuclei, and some dark brown areas indicating staining or cell clusters. Microscopic image of liver tissue showing clusters of blue-stained cell nuclei, clear fat vacuoles, and scattered brown-stained structures. Microscopic image showing numerous cells with dark-stained nuclei scattered across a light background, characteristic of neural tissue. Microscopic view of brain tissue with scattered neuron cell bodies stained in blue against a light background.
Product Code: 8477-C010: RTU, 10 capsules; 1 pack
8477-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: BP53.12
Host Clonality: mouse monoclonal
Control Tissue: selective squamous cell cardinoma
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
p53 is a nuclear phosphoprotein and generally wild-type is not detectable by IHC due to its short half-life. The antibody labels wild-type and mutant-type p53 protein in neoplastic cells.
Tissue-Tek Genie<sup>®</sup> anti-p53
Additional Images:
Microscopic image of tissue stained to highlight cell nuclei, showing densely packed dark brown nuclei within glandular structures against a lighter background. Microscopic image showing densely packed dark-stained cells within a tissue section, surrounded by lighter-stained areas and elongated nuclei. Light microscope image of tissue section showing oval-shaped glandular structures with surrounding nuclei, likely from an intestinal lining. Microscopic image of tissue showing multiple oval and circular structures with surrounding cells, likely a cross-section of glandular or intestinal tissue.
Product Code: 8312-C010: RTU, 10 capsules; 1 pack
8312-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: MX013
Host Clonality: mouse monoclonal
Control Tissue: tonsil, prostate, placenta, and squamous cell carcinoma
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
P63 is a transcription factor that plays a critical role in the growth and development of many epithelial tissues. It is found in basal epithelial cells in tissues such as cervix, bladder, breast, epidermis, and prostate.
Tissue-Tek Genie<sup>®</sup> anti-p63
Additional Images:
Histology image showing tissue section with clusters of dark-stained cell nuclei on the left side and lighter-stained nuclei on the right, indicating differing cellular composition. Microscopic image showing tissue stained with brown and blue dyes; brown-stained nuclei are grouped on the left, surrounded by mostly blue-stained cells on the right. Microscopic image of stained tissue section showing numerous oval-shaped cell nuclei scattered throughout a light background. Microscopic image showing numerous oval-shaped, blue-stained cell nuclei scattered throughout a light background.
Product Code: 8500-C010: RTU, 10 capsules; 1 pack
8500-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP156
Host Clonality: rabbit
Control Tissue: tonsil, appendix, B-cell lymphoma
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
PAX5, also designated B-cell specific activator protein (BSAP), is a transcription factor of the paired-box (PAX) containing family. PAX5 is important in control of B-cell commitment and shows nuclear expression in early progenitor B-cells and in all mature B-cells.
Tissue-Tek Genie<sup>®</sup> anti-PAX5
Additional Images:
Microscopic image showing clusters of dark brown-stained cells among many smaller blue-stained cells on a white background, likely indicating immunohistochemical staining. Microscopic view of tissue stained blue and brown, showing densely packed cells with clusters of dark brown-stained areas among lighter blue cells.
Product Code: 8287-C010: RTU, 10 capsules; 1 pack
8287-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP239
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, lymph-node, selective T-cell lymphomas
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Programmed-death ligand 1 (PD-1) is expressed by germinal center-associated helper T-cells and inhibits T-cell activity. PD-1 is expressed on T-cells, B-cells, and monocytes during activation. PD-1 positivity has been found in angioimmunoblastic lymphoma, primary cutaneous pleomorphic T-cell lymphoma, and nodular lymphocyte- predominant Hodgkin lymphoma but not other subtypes of T-cell and B-cell non-Hodgkin lymphomas or classic Hodgkin lymphomas.
Tissue-Tek Genie<sup>®</sup> anti-PD-1
Additional Images:
Microscope image shows tissue section with blue-stained nuclei and scattered brown-stained cells, indicating immunohistochemical staining in a histology specimen. Microscopic image of tissue section showing cells stained in shades of blue and brown, indicating different cellular components or markers. Microscopic image showing densely packed blue-stained cell nuclei within tissue, with some lighter areas indicating the surrounding extracellular matrix. Microscopic image showing numerous round, blue-stained cell nuclei scattered within light purple cytoplasm, likely representing a tissue sample or histological section.
Product Code: 8236-C010: RTU, 10 capsules; 1 pack
8236-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: 5B10
Host Clonality: mouse monoclonal
Control Tissue: tonsil, spleen, selective ALCL
Staining Pattern: granular cytoplasmic
Regulatory Status: IVD, FDA Class I
Perforin is a key molecule for cytotoxicity mediated by T-cells and natural killer cells. It is expressed in the cytoplasmic granule of cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells, and is a specific marker of functionally active CTLs and NK-cells.
Tissue-Tek Genie<sup>®</sup> anti-Perforin
Additional Images:
Microscopic image of cells stained with blue and brown dyes, showing various round cell nuclei clustered densely across the field. Microscopic view of stained cells showing numerous blue-stained round nuclei with scattered dark brown spots on a pale background. Microscope image showing densely packed blue-stained cells with a single dark brown cell near the center. Microscopic view of densely packed blue-stained cells with a single small dark brown spot near the center.
Product Code: 8235-C010: RTU, 10 capsules; 1 pack
8235-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: GM022
Host Clonality: mouse monoclonal
Control Tissue: placenta, seminoma
Staining Pattern: membraneous and cytoplasmic
Regulatory Status: IVD, FDA Class I
PLAP is a membrane-bound glycosylated dimeric enzyme expressed primarily in the placenta, and also in the endocervix and fallopian tubes. It is closely related to the intestinal form of the enzyme as well as to the placental-like form.
Tissue-Tek Genie<sup>®</sup> anti-PLAP
Additional Images:
Microscopic image of tissue section showing glandular structures and densely packed cells, likely from a histological sample stained to highlight cellular and structural details. Microscopic image of tissue section showing glandular structures and densely packed cells, stained to highlight cellular and structural details.
Product Code: 8328-C010: RTU, 10 capsules; 1 pack
8328-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP51
Host Clonality: rabbit monoclonal
Control Tissue: normal colon, appendix, tonsil
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
PMS2 is expressed in normal proliferating cells and, when heterodimerized with MLH1 (MutL protein homolog 1), is involved in repairing DNA mutations which may occur during DNA replication. Lost expression or low levels of PMS2 are associated with colorectal and other cancers.
Tissue-Tek Genie<sup>®</sup> anti-PMS2
Additional Images:
Microscopic image of stained tissue showing oval glandular structures with dark-stained nuclei and scattered cells in the surrounding connective tissue. Microscopic view of tissue showing multiple oval structures lined with dark-stained cells and surrounded by lighter areas, likely representing glandular tissue stained for histological analysis. Microscopic image showing tissue section with numerous dark brown-stained cells scattered within a background of light blue-stained cells. Microscopic view of tissue sample showing clusters of dark-stained cells scattered among lighter-stained cells, indicating possible cellular differentiation or marker expression.
Product Code: 8515-C010: RTU, 10 capsules; 1 pack
8515-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: D2-40
Host Clonality: mouse monoclonal
Control Tissue: tonsil, appendix, lymph node, epithelioid mesothelioma
Staining Pattern: mainly cytoplasmic and some membraneous
Regulatory Status: IVD, FDA Class I
Podoplanin is a transmembrane protein expressed by lymphatic endothelial cells, fibroblasts, osteocytes, follicular dendritic cells, smooth and striated muscle cells, myoepithelial cells, Cajal cells, squamous epithelial basal cells, prostatic basal epithelial cells, immature Sertoli cells, gastric crypt cells, renal glomerular podocytes, and Schwann cells. In tumors, podoplanin is detected in follicular dendritic cell tumors, dermatofibromas, lymphangiomas, Kaposi’s sarcoma, hemangioblastomas, seminomas, epithelioid mesotheliomas, and a subset of angiosarcomas with lymphatic differentiation.
Tissue-Tek Genie<sup>®</sup> anti-Podoplanin
Additional Images:
Microscopic image of tissue stained with blue and brown dyes, showing cellular structures and patterns for histological examination. Microscopic image showing blue-stained tissue sample with various cell structures and some darker brown areas scattered throughout. Microscopic image of tissue showing scattered dark blue nuclei and light brown cytoplasmic staining, typical of immunohistochemistry analysis. Microscopic image showing numerous small, round blue-stained cell nuclei within tissue; light brown staining is scattered throughout the sample.
Product Code: 8244-C010: RTU, 10 capsules; 1 pack
8244-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP109
Host Clonality: rabbit monoclonal
Control Tissue: prostate hyperplasia, prostate cardinoma
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Prostate Specific Antigen (PSA) is expressed in different types of prostate carcinoma, both primary and metastatic. It is found in approximately 99% of prostatic adenocarcinoma cases, with high grade carcinomas often displaying weaker expression.
Tissue-Tek Genie<sup>®</sup> anti-Prostate Specific Antigen
Additional Images:
Microscopic view of tissue showing clusters of cells with blue-stained nuclei scattered throughout the sample. Microscopic view of human kidney tissue showing glomeruli and surrounding cells, with cell nuclei stained blue.
Product Code: 8519-C010: RTU, 10 capsules; 1 pack
8519-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: ZR9
Host Clonality: rabbit monoclonal
Control Tissue: benign prostate and prostate carcinoma
Staining Pattern: granular cytoplasmic
Regulatory Status: IVD, FDA Class I
Prostein, also known as P501S, is expressed in the vast majority of normal and malignant prostatic tissues. Prostein is localized in the Golgi complex and has a perinuclear-like cytoplasmic staining pattern. Prostein is a prostate-specific marker and has not been detected in any other normal or malignant tissues.
Tissue-Tek Genie<sup>®</sup> anti-Prostein
Additional Images:
Microscopic view of tissue sample with brown-stained cell membranes and nuclei stained blue, showing cellular structure and distribution for histological analysis. Microscopic image showing tissue with brown-stained cell membranes, indicating positive immunohistochemical staining, surrounded by unstained and lightly stained areas. Microscopic view of a tissue section stained to highlight cell nuclei in blue, showing a layer of tightly packed epithelial cells. Microscopic image shows a layer of densely packed blue-stained cells with visible nuclei, likely representing a tissue sample section.
Product Code: 8442-C010: RTU, 10 capsules; 1 pack
8442-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP32
Host Clonality: rabbit monoclonal
Control Tissue: skin, gastrointestinal tract, melanoma
Staining Pattern: cytoplasmic and nuclear
Regulatory Status: IVD, FDA Class I
S100 is a multigene family of calcium binding proteins. S100B is one member of the S100 family and is expressed in glial cells of nervous system, melanocytes, chondrocytes, and adipocytes. The antibody labels S100B in normal and neoplastic cells.
Tissue-Tek Genie<sup>®</sup> anti-S100B
Additional Images:
Microscopic image of tissue sections showing oval-shaped structures with blue-stained cell nuclei and dark brown outlines, likely indicating immunohistochemical staining. Microscopic image of tissue section stained to highlight specific cellular structures, showing oval-shaped glandular formations with blue and brown coloration. Microscopic view of tissue stained with hematoxylin and DAB, showing cells with varying morphology and areas of brown immunoreactive staining. Microscopic image of tissue stained with hematoxylin and immunohistochemistry, showing cellular structures and dark brown areas indicating positive staining.
Product Code: 8356-C010: RTU, 10 capsules; 1 pack
8356-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: QR023
Host Clonality: rabbit monoclonal
Control Tissue: appendix/colon, tonsil, testis, or colorectal carcinoma
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I

Special AT-rich sequence-binding protein 2 (SATB2) is a nuclear transcription factor that is strongly expressed in the epithelium of the lower gastrointestinal tract (GI) including the colon, appendix, and rectum.

Tissue-Tek Genie<sup>®</sup> anti-SATB2
Additional Images:
Microscopic image of intestinal tissue section stained to highlight specific proteins, showing brown-stained cells lining the villi and a blue counterstain in the background. Microscopic image of tissue sections showing clusters of cells with brown-stained nuclei, indicating positive immunohistochemical staining; magnification 20x.
Product Code: 8264-C010: RTU, 10 capsules; 1 pack
8264-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP268
Host Clonality: rabbit monoclonal
Control Tissue: epidermis, colon, melanoma
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
SOX10 is a neural crest transcription factor involved in the determination of cell fate, maturation, and maintenance of Schwann cells and melanocytes. The antibody labels SOX10 in both normal and neoplastic cells.
Tissue-Tek Genie<sup>®</sup> anti-SOX10
Additional Images:
Microscopic view of stained tissue section showing densely packed and elongated cells with distinct nuclei, arranged in glandular patterns on a white background. Microscopic image of tissue sample showing glandular structures and numerous blue-stained cell nuclei, likely from a histological or pathology slide. Microscopic image of a tissue section showing multiple layers of cells with dark-stained nuclei, most concentrated in the upper and middle regions. Microscopic image of a tissue section showing multiple layers of cells, with dark-stained nuclei concentrated in the upper layers, likely depicting skin or epithelial tissue.
Product Code: 8521-C010: RTU, 10 capsules; 1 pack
8521-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: CM032
Host Clonality: mouse monoclonal
Control Tissue: selected mantle cell lymphomas
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
Sry-related HMg-box gene 11 (SOX11) is a nuclear transcription factor expressed in the developing human central nervous system and plays a role in embryonic cell determination. SOX11 is not expressed in normal adult human tissues. SOX11 over-expression is reported in over 90% of mantle cell lymphomas, including the rare cyclin D1-negative cases. SOX11 expression has also been identified in other tumors including malignant gliomas, neuroendocrine carcinomas, sarcomas, adenocarcinomas, lymphoblastic leukemias /lymphomas, Burkitt lymphomas and hairy cell leukemias.
Tissue-Tek Genie<sup>®</sup> anti-SOX11
Additional Images:
Microscopic view of stained tissue showing numerous small, round cells with dark brown and blue nuclei, possibly indicative of immunohistochemistry analysis. Microscopic view of densely packed cells showing brown-stained nuclei among lighter blue cells, likely illustrating immunohistochemical staining of a tissue sample. Microscopic image showing densely packed blue-stained cells, likely representing a section of tissue viewed under high magnification. Microscopic view of densely packed blue-stained cells, displaying a uniform distribution across the image, likely showing tissue sample histology.
Product Code: 8228-C010: RTU, 10 capsules; 1 pack
8228-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: EP103
Host Clonality: rabbit monoclonal
Control Tissue: embryonal carcinoma, esophagus, SCC, tonsil
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
Sry-related HMg-box gene 2 (SOX2) is expressed in multipotent neuronal stem cells in normal tissues. Overexpression of SOX2 is found in testicular germ cell tumors, teratomas, astrocytic tumors, melanomas, various squamous cell carcinomas, and breast cancers with a basal cell phenotype.
Tissue-Tek Genie<sup>®</sup> anti-SOX2
Additional Images:
Microscopic image of tissue sections showing tubular structures with scattered darkly stained cell nuclei on a pale background. Microscopic image showing cross-sections of tissue with oval-shaped structures containing densely packed cells, some stained darker, against a light background. Microscopic image showing densely packed cells with visible nuclei stained in blue, typical of a tissue sample under high magnification. Microscopic image of cells with dark-stained nuclei and lightly stained cytoplasm, showing typical cellular structure and organization.
Product Code: 8453-C010: RTU, 10 capsules; 1 pack
8453-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: BS15
Host Clonality: mouse monoclonal
Control Tissue: appendix, colon, pancreas, neuroendocrine tumors
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Synaptophysin is a calcium-binding glyco-protein expressed in the membranes of neuronal presynaptic vesicles, as well as in vesicle membranes of neuroendocrine cells and the choroid plexus epithelium.
Tissue-Tek Genie<sup>®</sup> anti-Synaptophysin
Additional Images:
Microscopic view of tissue section stained with hematoxylin and eosin, showing glandular structures and cell nuclei in shades of blue and purple. Histology slide showing stained tissue with round and oval cell structures, likely glandular, and numerous dark-stained nuclei dispersed throughout.
Product Code: 8243-C010: RTU, 10 capsules; 1 pack
8243-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: SEN28
Host Clonality: mouse monoclonal
Control Tissue: thymus, thymoma, some cells within tonsils
Staining Pattern: nuclear
Regulatory Status: IVD, FDA Class I
Terminal deoxynucleotidyl transferase (TdT) is a deoxynucleotide polymerizing enzyme that generates antigen receptor diversity at the junctions of rearranged immunoglobulin heavy chain and T-cell receptor gene segments. TdT protein expression is normally found only in B-cell and T-cell lymphoblasts/lymphoid progenitor cells. TdT protein-positive cells are regularly detected in thymus and bone marrow, and may occasionally be seen in tonsils, lymph nodes, and extranodal lymphoid tissue.
Tissue-Tek Genie<sup>®</sup> anti-Terminal Deoxyribonucleotidyl Transferase
Additional Images:
Microscopic image of tissue sample showing densely packed cells with some lighter and darker regions, possibly indicating staining differences or varied cell types. Microscopic view of tissue sample showing densely packed cells with lighter and darker regions, possibly stained for examination or diagnostic purposes.
Product Code: 8224-C010: RTU, 10 capsules; 1 pack
8224-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP229
Host Clonality: rabbit monoclonal
Control Tissue: thyroid, lunc, thyroid, lung adenocarcinomas
TTF-1 is a transcription factor expressed in thyroid, lung,
and certain areas of brain.
Tissue-Tek Genie<sup>®</sup> anti-Thyroid Transcription Factor-1
Additional Images:
Microscopic view of thyroid tissue showing follicles with colloid centers, surrounded by follicular cells stained dark brown. Microscopic view of thyroid gland tissue showing follicles surrounded by follicular cells, stained for cellular detail. Microscopic image of tissue section stained in blue, showing clusters of densely packed cells and various irregularly shaped empty spaces. Microscopic view of tissue section stained with hematoxylin, showing clustered and scattered cell nuclei in various gland-like structures.
Product Code: 8372-C010: RTU, 10 capsules; 1 pack
8372-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: EP259
Host Clonality: rabbit monoclonal
Control Tissue: tonsil, appendix, colon
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Tryptase is a trypsin-like neutral serine proteinase stored predominantly in secretory granules of mast cells and basophils, and upon cellular activation is released into the extracellular environment.
Tissue-Tek Genie<sup>®</sup> anti-Tryptase
Additional Images:
Microscopic image of tissue section stained with hematoxylin and DAB, showing epithelial cell layers and scattered brown-stained nuclei. Microscopic view of tissue sample stained blue, showing clustered cells with irregular, finger-like projections and scattered dark spots.
Product Code: 8336-C010: RTU, 10 capsules; 1 pack
8336-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: V9
Host Clonality: mouse monoclonal
Control Tissue: lymph node, appendix, tonsil
Staining Pattern: cytoplasmic
Regulatory Status: IVD, FDA Class I
Vimentin is an intermediate filament which forms part of the cytoskeleton and is expressed ubiquitously in mesenchymal cells such as fibroblasts, smooth muscle cells, and endothelium. The antibody labels vimentin in normal and neoplastic cells.
Tissue-Tek Genie<sup>®</sup> anti-Vimentin
Additional Images:
Microscopic view of tissue sample showing clusters of irregularly shaped, dark-stained cells and lighter cellular structures scattered throughout the image. Microscopic view of tissue sample showing numerous oval-shaped cells with dark-stained borders and some densely packed darker regions.
Product Code: 8340-C010: RTU, 10 capsules; 1 pack
8340-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: CP122
Host Clonality: rabbit monoclonal
Control Tissue: kidney, fallopian tube, and serous carcinomas
Staining Pattern: Nuclear staining is interpreted as positive. Nucleolar staining and/or membraneous staining alone are not considered positive
Regulatory Status: IVD, FDA Class I
Wilms’ tumor-1 protein (WT1) is a transcription factor that plays a role in the development of genitourinary organs and is involved in the induction of Wilms’ tumor (nephroblastoma), a pediatric renal malignancy. It is largely restricted to the surface epithelium and inclusion cysts of ovaries and fallopian tubes, and is absent in endometrial and cervical epithelia.
Tissue-Tek Genie<sup>®</sup> anti-WT1
Additional Images:
Microscopic image showing densely packed cells with dark-stained nuclei, typical of a tissue sample stained for histological examination. Microscopic view of tissue with clusters of densely stained cell nuclei surrounded by lighter, less densely packed cells, indicating possible cellular differentiation or pathology. Microscopic image of tissue section showing two clusters of densely packed dark-stained cell nuclei surrounded by lighter staining, likely representing pancreatic islets within exocrine tissue. Microscopic image of tissue shows clusters of densely packed, irregularly shaped cells with visible nuclei, stained in shades of blue and light purple. Microscopic view of tissue sample stained in shades of blue, showing clustered cells with irregular shapes and clear spaces in between.
Product Code: 8501-C010: RTU, 10 capsules; 1 pack
8501-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: ZM97
Host Clonality: mouse monoclonal
Control Tissue: lymph node, tonsil, selected cases of B-CLL/SLL
Staining Pattern: cytoplasmic and nuclear
Regulatory Status: IVD, FDA Class I
ZAP70 is expressed in T-cells, natural killer (NK) cells, and pro/pre B-cells, but not in normal mature B-cells. Expression of ZAP70 has been reported in various lymphomas, including mantle cell lymphoma, marginal zone lymphoma, and approximately 25% of chronic lymphocytic leukemias. In CLL, ZAP70 expression is closely associated with an unmutated configuration of the IgVH genes.
Tissue-Tek Genie<sup>®</sup> anti-ZAP70
Additional Images:
Microscopic image of tissue stained with hematoxylin and DAB, showing numerous blue-stained cells and scattered brown-stained nuclei. Microscopic view of tissue showing numerous small, round cells stained blue with some scattered dark brown or black spots throughout. Microscopic image showing clusters of dark-stained cells with distinct nuclei on a light background, likely representing tissue or cellular sample under magnification. Microscopic view of numerous blue-stained cells scattered across a light background, likely showing a tissue sample or cell culture under high magnification.
Product Code: 8485-C010: RTU, 10 capsules; 1 pack
8485-M100: RTU, 100 tests, 1 cartridge; 1 unit
Clone: 13H4/MX013/(D5/16B4)
Host Clonality: mouse and rabbit monoclonal
Control Tissue: normal (benign) prostate and prostate adenocarcinoma
Staining Pattern: cytoplasmic for AMACR, nuclear for p63, and cytoplasmic for CK5/6
Regulatory Status: IVD, FDA Class I
The immunohistochemical combination of nuclear p63 expression and cytoplasmic CK5/6 expression aids in detection of peripheral basal cells, while cytoplasmic expression of AMACR in glandular cells facilitates the detection of potentially neoplastic proliferations.
Tissue-Tek Genie<sup>®</sup> DUO anti-AMACR/p63/CK5/6 PIN Antibody Cocktail
Additional Images:
Microscopic image of kidney tissue showing glomerulus and surrounding tubules, stained to highlight cellular structures in pink, gray, and blue. Microscopic image of kidney tissue stained to highlight structures; tubules appear pink and glomerulus appears as a circular cluster in the center. Microscopic view of tissue sample showing branched, irregular structures outlined by dark staining, surrounded by lighter areas with scattered cells. Microscopic image showing tissue sections with branching structures and cell nuclei stained in varying shades of blue and brown.
Product Code: 8480-C010: RTU, 10 capsules; 1 pack
8480-M100: RTU, 100 tests, 1 cartridge; 1 unit
Clone: EP43/GM010
Host Clonality: mouse and rabbit monoclonal
Control Tissue: melanoma, skin
Staining Pattern: cytoplasmic for Melan-A and nuclear for Ki67
Regulatory Status: IVD, FDA Class I
Melan-A, also known as Melanoma Antigen Recognized by T-cell 1 (MART-1), is a protein associated with endoplasmic reticulum and melanosomes and is expressed in melanocytes. Melan-A is expressed in all normal melanocytes and is detected in 80-100% of melanomas. Ki67 is a proliferation-associated nuclear protein is expressed during all active phases of the cell cycle and is absent in resting cells.
Tissue-Tek Genie<sup>®</sup> DUO anti-Melan-A / Ki67 Antibody Cocktail
Additional Images:
Microscopic image showing tissue sections with brown-stained areas and scattered dark spots, likely indicating different cell types or regions within the sample. Microscopic view of lymph node tissue showing three brown-stained germinal centers surrounded by lighter-stained areas, indicating differential cell presence. Microscopic image of skin tissue showing layers of cells; brown-stained nuclei indicate positive immunohistochemical staining. Microscopic image of human skin tissue showing layers of cells with numerous dark-stained nuclei, indicating cell proliferation or activity in the basal and lower epidermal layers.
Product Code: 8484-C010: RTU, 10 capsules; 1 pack
8484-M100: RTU, 100 tests, 1 cartridge; 1 unit
Clone: (AE1/AE3/DC10)/RM247
Host Clonality: mouse and rabbit monoclonal
Control Tissue: tonsil, appendix, liver, carcinoma
Staining Pattern: cytoplasmic and some membraneous staining for cytokeratins and membraneous and cytoplasmic staining for CD31
Regulatory Status: IVD, FDA Class I
Cytokeratins (CK) are a group of intermediate filament proteins expressed in cells of epithelial origin. CD31, also known as platelet/endothelial cell adhesion molecule 1 (PECAM-1), is a transmembrane protein expressed on endothelial cells and is considered to be a pan-endothelial cell marker.
Tissue-Tek Genie<sup>®</sup> DUO anti-Pan Cytokeratin/CD31 Antibody Cocktail
Additional Images:
Microscopic image showing polygonal cells with brown and pink staining, highlighting cellular and structural details for histological analysis. A close-up of a microscope. Microscopic image showing numerous small red-stained rod-shaped bacteria scattered among round, translucent cells on a light background. A microscopic view of brain tissue showing scattered red-stained bacteria among gray cellular structures on a light background.
Product Code: 8482-C010: RTU, 10 capsules; 1 pack
8482-M250: RTU, 250 tests, 1 cartridge; 1 unit
Clone: polyclonal
Host Clonality: antibody cocktail
Control Tissue: NA
Staining Pattern: no staining
Regulatory Status: IVD, FDA Class I
The concentration of mouse and rabbit Ig is similar to that of the Tissue-Tek Genie DUO mouse and rabbit primary antibody cocktails used on the Tissue-Tek Genie Advanced Staining System.
Tissue-Tek Genie<sup>®</sup> DUO Non-immune Mouse and Rabbit Ig Antibody Cocktail, Negative Control
Product Code: 8539-C010: RTU, 10 capsules; 1 pack
Clone: polyclonal
Host Clonality: goat polyclonal
Control Tissue: kidney or skin from Lupus cases with C3 deposits
Staining Pattern: membraneous and/or cytoplasmic
Regulatory Status: IVD, FDA Class I
C3, also known as complement component 3, is a protein of the immune system and plays a central role in the complement immune system and contributes to innate immunity. Human C3 can be detected in dermal vessels in kidney and skin tissue in lupus nephritis cases containing C3 deposits, as well as associated with a kidney and skin tissues under pathologic conditions such as post-infectious glomerulonephritis and bullous pemphigoid.
Tissue-Tek Genie<sup>®</sup> FITC anti-C3
Additional Images:
A fluorescence microscopy image showing green-stained tissue with a distinct boundary and cellular structures visible on the right side. Green fluorescent cells and tissue structures viewed under a microscope, showing a bright edge and mottled texture throughout the image.
Product Code: 8538-C010: RTU, 10 capsules; 1 pack
Clone: polyclonal
Host Clonality: goat polyclonal
Control Tissue: placenta
Staining Pattern: membraneous and/or cytoplasmic
Regulatory Status: IVD, FDA Class I
Fibrinogen is a soluble blood coagulation glycoprotein. It comprises of paired sets of three sub-unites (alpha, beta and gamma). Fibrinogen polymerizes into fibrin and acts as a cofactor in platelet aggregation.
Tissue-Tek Genie<sup>®</sup> FITC anti-Fibrinogen
Additional Images:
Green fluorescent patterns are visible in a microscopic image, showing an irregular distribution across a dark background. Green fluorescent microscopic image showing a network of irregular, interconnected structures on a dark background.
Product Code: 8536-C010: RTU, 10 capsules; 1 pack
Clone: polyclonal
Host Clonality: goat polyclonal
Control Tissue: tonsil, lymph node
Staining Pattern: membraneous and/or cytoplasmic
Regulatory Status: IVD, FDA Class I
IgA is a glycoprotein that plays a crucial role in the immune function of mucous membranes. Monomeric IgA constitutes 5-15% of serum immunoglobulins whereas dimeric IgA is the main immunoglobulin found in mucous secretions.
Tissue-Tek Genie<sup>®</sup> FITC anti-IgA
Additional Images:
Fluorescent microscopy image showing scattered bright green spots within a dark green background, indicating labeled structures or cells. Fluorescence microscopy image showing green punctate structures distributed within a cell on a dark background.
Product Code: 8535-C010: RTU, 10 capsules; 1 pack
Clone: polyclonal
Host Clonality: goat polyclonal
Control Tissue: tonsil, lymph node
Staining Pattern: membraneous and/or cytoplasmic
Regulatory Status: IVD, FDA Class I
IgG is a glycoprotein that regulates immunological defense mechanisms and plays a crucial role in humoral immune response. IgG is secreted by B-cells and is the most abundant serum immunoglobulins of the immune system.
Tissue-Tek Genie<sup>®</sup> FITC anti-IgG
Additional Images:
Green fluorescent microscopy image showing irregular, web-like patterns and a thick band along the right edge, likely representing biological tissue or cellular structures. Green fluorescence microscopy image showing fibrous and cellular structures against a dark background, commonly used for viewing tissue samples or cellular components.
Product Code: 8537-C010: RTU, 10 capsules; 1 pack
Clone: polyclonal
Host Clonality: goat polyclonal
Control Tissue: tonsil, lymph node
Staining Pattern: membraneous and/or cytoplasmic
Regulatory Status: IVD, FDA Class I
IgM is a glycoprotein that is produced by B-cells. IgM constitutes ~10% of serum immunoglobulins. Monomeric IgM is expressed as a membrane bound antibody on the surface of B-cells and as a pentamer when secreted by plasma cells.
Tissue-Tek Genie<sup>®</sup> FITC anti-IgM
Additional Images:
Green fluorescent dots are scattered against a dark background, likely viewed under a microscope to show labeled cells or particles. Green fluorescent dots scattered across a dark background, viewed under a microscope, possibly indicating labeled cells or particles.
Product Code: 8282-C010: RTU, 10 capsules; 1 pack
8282-M250: RTU, 1 cartridge, 250 tests; 1 unit
Clone: RM247
Host Clonality: rabbit monoclonal
Control Tissue: appendix, tonsil, liver, placenta
Staining Pattern: mainly membraneous and some cytoplasmic
Regulatory Status: IVD, FDA Class I
CD31, also known as platelet/endothelial cell adhesion molecule 1 (PECAM-1), is a trans-membrane protein expressed on endothelial cells.
Tissue-Tek Genie<sup>®</sup>  anti-CD31
Additional Images:
Microscopic image of a tissue sample showing brown-stained cells concentrated at the base of glandular structures, with nuclei stained blue throughout the sample. Microscopic image of tissue section showing brown-stained cells among blue-stained cells, indicating regions of protein expression in a histological sample.

Tissue-Tek Genie® Pro Detection Kit, DAB

A rectangular label with a black border containing the bold letters "IVD" in the center.

Product code and quantity

8826-K250: 6 cartridges, 250 tests, RTU; 1 kit

Description

The Tissue-Tek Genie Pro Detection Kit, DAB uses a non-biotin based system to detect and to visualize mouse or rabbit primary antibodies bound to antigens in Formalin-Fixed, Paraffin-Embedded (FFPE) specimen sections.

The detection system uses Protein and Peroxidase blocks to prevent unspecific binding of antibodies to antigens and reactions of endogenous peroxidase with downstream components of the detection system. After blocking, the detection system uses a Link solution that binds to the mouse or rabbit primary antibodies to form a complex with a horse radish peroxidase (HRP) conjugate which increases sensitivity.

The complex is then visualized with the addition of DAB. DAB Intensifier can be used to increase the intensity of
DAB staining.

Components

The detection system kit contains 6 cartridges, one cartridge each of the following:
• Tissue-Tek Genie® Protein Block, 250 tests
• Tissue-Tek Genie® Peroxidase Block, 250 tests
• Tissue-Tek Genie® Link, 250 tests
• Tissue-Tek Genie® Poly HRP-Conjugate, 250 tests
• Tissue-Tek Genie® DAB, 250 tests
• Tissue-Tek Genie® DAB Intensifier, 250 tests

Six labeled cartridges, each with a barcode and a descriptive label: Protein Block, Peroxidase Block, Link, HRP-Conjugate, DAB Substrate, and DAB Intensifier, arranged side by side.

These 6 images display the exceptional sensitivity (high dynamic range) and superb specificity (no visible non-specific background staining) of the Tissue-Tek Genie Pro Detection Kit, DAB and selected Tissue-Tek Genie antibodies.

A blue and white cell.

Positive Helicobacter pylori staining in crypts of gastric mucosa, no background staining.

A close-up of a cell.

Negative staining of colon adenocarcinoma with loss of MLH1 expression, no background staining.

A close-up of a microscope.

Negative staining of colon adenocarcinoma with loss of MSH2 expression, no background staining.

Microscopic image of tissue stained with hematoxylin and eosin, showing clusters of dark-stained cells among lighter tissue structures.

Negative staining of colon adenocarcinoma with loss of PMS2 expression, no background staining.

Microscopic image of tissue with clusters of brown-stained nuclei among mostly blue-stained cells, indicating positive immunohistochemical staining.

Negative staining of colon adenocarcinoma with loss of PMS2 expression, no background staining.

Microscopic image of stained intestinal tissue showing dark brown villi structures and scattered blue-stained nuclei.

CK 19 staining in crypt cells of appendix with high dynamic range, no background staining.



The Tissue-Tek Genie Pro Detection Kit, DAB HRP staining steps provide standardization using RTU components and timing flexibility where needed.

A timeline of immunohistochemistry steps: Dewax, Antigen Retrieval, Protein Block, Primary Antibody, Link, AP-Conjugate, AP Red, and Counterstain, with wash steps in between and times listed.

Tissue-Tek Genie® Pro AP Red Detection KitTissue-Tek Genie® Pro AP Red Detection Kit

A rectangular label with a black border containing the bold letters "IVD" in the center.

Product code and quantity

8836-K250: 4 cartridges, 250 tests, RTU; 1 kit

Description

The Tissue-Tek Genie Pro AP Red Detection Kit uses a non-biotin based system to detect and to visualize mouse and rabbit primary antibodies bound to antigens informalin-fixed, paraffin-embedded (FFPE) specimen sections.

The detection system uses protein block to prevent nonspecific binding of antibodies to antigens with downstream components of the detection system. After blocking, the detection system uses a link solution that binds to the mouse and rabbit primary antibodies to form a complex with an alkaline phosphatase AP-Conjugate. The complex is then visualized with the addition of AP Red.

Components

The detection system kit contains 4 cartridges, one cartridge each of the following:

  • Tissue-Tek Genie® Protein Block
  • Tissue-Tek Genie® Link
  • Tissue-Tek Genie® Poly AP-Conjugate
  • Tissue-Tek Genie® AP Red
Several white containers with black labels.

These 3 images display the exceptional sensitivity (high dynamic range) and superb specificity (no visible non-specific background staining) of the Tissue-Tek Genie Pro AP Red Detection Kit and selected Tissue-Tek Genie antibodies.

A close-up of a cell.

Strong pan melanoma staining of melanoma.

A close-up of a microscope.

Melan-A staining of blue nevus.

A close-up of a white and purple speckled surface.

SOX10 staining of melanoma.

The Tissue-Tek Genie Pro AP Red Detection Kit, staining steps provide standardization using RTU components and timing flexibility where needed.

Timeline diagram showing steps in a staining protocol: Dewax, Antigen Retrieval, Protein Block, Primary Antibody, Link, AP-Conjugate, AP Red, and Counterstain, each with time durations.

Tissue-Tek Genie® DUO Detection Kit

A rectangular label with a black border containing the bold letters "IVD" in the center.

Product code and quantity

8837-K250: 6 cartridges, 250 tests, RTU; 1 kit

Tissue-Tek Genie® DUO Mouse-DAB/Rabbit-AP Red Dual Detection Kit

The Tissue-Tek Genie® DUO Mouse-DAB/Rabbit-AP Red Dual Detection Kit uses a non-biotin-based system to detect and to visualize mouse and rabbit primary antibodies bound to antigens in FFPE specimen sections.

The detection system uses a protein block to prevent nonspecific binding of antibodies to antigens with downstream components of the detection system. After blocking, mouse and rabbit primary antibodies are applied on the tissue sections simultaneously using prefilled capsules or cartridges. Subsequently, the detection system sequentially applies the Link Mouse solution that binds to mouse primary antibodies and then the Link Rabbit solution that binds to rabbit primary antibodies. This is followed by an application of a cocktail containing a horseradish peroxidase (HRP) conjugate for mouse and an alkaline phosphatase AP-Conjugate for rabbit. The resulting complex is visualized by sequentially applying the diaminobenzidine (DAB) substrate-chromogen solution, and then by applying the AP Red substrate-chromogen solution, which create colored precipitates at the location of the antigens.

Six labeled reagent cartridges with attached syringes are aligned vertically in a holder, each labeled for different laboratory uses such as Protein Block and DAB.
A table lists steps of an immunostaining protocol with columns for Dewax, Antigen Retrieval, Protein Block, Primary Antibody, Link Mouse, Link Rabbit, HRP and AP-Conjugate, DAB, AP Red, and Counterstain.

A close-up of a microscope.

Tissue-Tek Genie® DUO anti-Melan-A [EP43] /Ki67 [GM010] Antibody Cocktail.
Note that the benign melanocytes are not proliferatively active.

A close-up of a cell.

Tissue-Tek Genie® DUO anti-Pan Cytokeratin [AE1/AE3/DC10] / CD31[RM247] Antibody Cocktail.
The combination of these two markers on a single slide is particularly helpful for identifying small foci of carcinoma within lymphatics.

A close-up of a microscope.

Tissue-Tek Genie® DUO Non-immune Mouse and Rabbit Ig Antibody Cocktail.

Tissue-Tek Genie® Pro Antibody Diluent

A rectangular label with a black border containing the bold letters "IVD" in the center.

Product code and quantity

8866-G004: RTU, 4 bottles, 100 mL each; 1 case

Description

Optimal staining performance during immunohistochemistry (IHC) is achieved through dilution of the primary antibodies. This dilution process involves mixing concentrated antibody with Tissue-Tek Genie® Pro Antibody Diluent to an optimal dilution determined by the user. The diluted antibody can then be filled into a Tissue-Tek Genie® User-Fillable Capsule, Tissue-Tek Genie® User Fillable Cartridge, or be applied by hand during manual application mode on the Tissue-Tek Genie® Advanced Staining System.

Tissue-Tek Genie® Hematoxylin

A rectangular label with a black border containing the bold letters "IVD" in the center.

Product code and quantity

8830-M250: RTU, 250 tests, 1 cartridge: 1 unit

Description

The Tissue-Tek Genie® Hematoxylin is designed to counterstain cellular nuclei in formalinfixed, paraffin embedded (FFPE) human specimen sections after immunohistochemistry (IHC) staining of specific protein targets or chromogenic in situ hybridization (CISH) of specific DNA or RNA targets using the automated Tissue-Tek Genie® Advanced Staining System.

Tissue-Tek Genie® Citrate Antigen Retrieval Solution

A rectangular label with a black border containing the bold letters "IVD" in the center.

Product code and quantity

8742-G001: RTU, 1 bottle, 3.8 Liters; 1 unit

Description

Tissue-Tek Genie® Citrate Antigen Retrieval Solution is designed for heat-induced epitope retrieval (HIER) of specimen sections during immunohistochemical (IHC) staining on the Tissue-Tek Genie® Advanced Staining System.

Tissue fixation involves creating crosslinks between protein residues in the tissue. This fixation process preserves the tissue, but also denatures many antigens and makes antigen sites within the tissue less accessible to antibodies. The Tissue-Tek Genie Citrate Antigen Retrieval Solution is applied to the specimen section and heated on the Tissue-Tek Genie Advanced Staining System. This process breaks the crosslinks formed during fixation and allows proteins to renature which allows greater accessibility of antigenic sites to antibodies.

Tissue-Tek Genie® Dewax Solution

A rectangular label with a black border containing the bold letters "IVD" in the center.

Product code and quantity

8865-G001: RTU, 1 bottle, 3.8 Liters; 1 unit

Description

Tissue-Tek Genie® Dewax Solution is designed to remove paraffin wax from paraffin embedded tissue sections on the Tissue-Tek Genie® Advanced Staining System.

Formalin-fixed, paraffin embedded (FFPE) specimen sections mounted on microscope slides are treated with Tissue-Tek Genie Dewax Solution on the Tissue-Tek Genie Advanced Staining System prior to the immunohistochemistry and/or in situ hybridization staining processes. Specimen sections in the presence of Tissue-Tek Genie Dewax Solution are gently heated for optimized removal of paraffin.

Tissue-Tek Genie® High pH Antigen Retrieval Solution

A rectangular label with a black border containing the bold letters "IVD" in the center.

Product code and quantity

8744-G001: RTU, 1 bottle, 3.8 Liters; 1 unit

Description

Tissue-Tek Genie® High pH Antigen Retrieval Solution is designed for heat-induced epitope retrieval (HIER) of specimen sections during immunohistochemical (IHC) staining on the Tissue-Tek Genie® Advanced Staining System.

Tissue-Tek Genie® Wash Buffer Solution

A rectangular label with a black border containing the bold letters "IVD" in the center.

Product code and quantity

8874-G004: RTU, 4 bottles, 3.8 Liters each: 1 case

Description

Tissue-Tek Genie® Wash Buffer Solution is designed to remove residual reagents from tissue sections during immunohistochemical (IHC) staining on the Tissue-Tek Genie® Advanced Staining System.

The Tissue-Tek Genie Wash Buffer Solution is a bulk reagent that is used between incubation steps during IHC or ISH staining processes. The Tissue-Tek Genie Wash Buffer Solution serves as a rinsing agent for the removal of residual reagents that remain on the tissue sections from the previous protocol step.

Tissue-Tek Genie® Proteinase K

A rectangular label with a black border containing the bold letters "IVD" in the center.

Product code and quantity

9811-M100: RTU, 100 tests, 1 cartridge; 1 unit

Description

The Tissue-Tek Genie® Proteinase K is intended for the proteolytic digestion of formalin-fixed, paraffin embedded (FFPE) human tissue sections during immuno-histochemistry (IHC) staining of specific protein targets or chromogenic in situ hybridization (CISH) staining of specific DNA or RNA targets on the automated Tissue-Tek Genie® Advanced Staining System.

Related items

A laboratory instrument labeled "Tissue-Tek Genie" with a glass front panel, internal sample holders, and multiple storage compartments below.

Tissue-Tek Genie® Advanced Staining System

Introducing the Tissue-Tek Genie® Advanced Staining System: the first and only fully automated, true random access stainer for IHC and ISH featuring 30 completely independent slide stations for uncompromised fast and predictable turnaround time with 5 antibody and probe dispensing options for unprecidented staining quality.  

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