brain, ganglia of appendix/GI tract, and astrocytoma
Regulatory status: IVD, FDA Class I
8316-C010: RTU, 10 capsules; 1 pack
8316-M250: RTU, 250 tests, 1 cartridge; 1 unit
GFAP is specifically expressed in astrocytes and ependymal cells. It is also expressed in Schwann cells and satellite cells in sensory ganglia of the peripheral nervous system, and in myoepithelial cells and chondroblasts. Immature oligodendrocytes and choroid plexus cells may be GFAP positive. Astrocytoma, ependymoma, glioblastoma, and oligodendroglioma are almost always GFAP positive.
Astrocytes show strong cytoplasmic reactivity in this benign brain specimen.
Myoepithelial cells of breast may show variable, weak to strong cytoplasmic reactivity for GFAP, often in a patchy distribution.
The neoplastic cells of this meningioma show no reactivity for GFAP.