Clone: ZM32
Host clonality: mouse monoclonal
Control tissue: tonsil, appendix, pancreas, breast, lung
Staining pattern: membraneous and cytoplasmic
Regulatory status: IVD, FDA Class I
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Product code:
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8375-C010: RTU, 10 capsules; 1 pack
8375-M250: RTU, 250 tests, 1 cartridge; 1 unit
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Mucin 1 (MUC1) is a cell surface mucin glycoprotein and is expressed on the apical borders of most glandular epithelial cells, ductal epithelial cells, and some hematopoietic cell lineages. In neoplastic tissues, MUC1 may be expressed on the entire cell surface (depolarized expression). MUC1 is overexpressed in many human cancers, including non-small cell lung carcinoma (NSCLC) and breast carcinoma.
Pancreatic acini show a diffuse strong granular cytoplasmic staining reaction for MUC1, while the bile ducts show a cytoplasmic and apical membrane reaction. The fibrous stroma is negative.
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Squamous epithelia, as in this benign cervical specimen, may show a weak to moderate cytoplasmic and membraneous staining reaction for MUC1 that is typically in the superficial layers.
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Normal hepatocytes show a negative staining reaction for MUC1 in this benign liver. Focal granular cytoplasmic reactivity is seen among bile ducts.