Tissue-Tek Genie® DUO
anti-AMACR/p63/CK5/6 PIN Antibody Cocktail

Clone: 13H4/MX013/(D5/16B4)
Host clonality: mouse and rabbit monoclonal
Control tissue: normal (benign) prostate and prostate adenocarcinoma
Staining pattern: cytoplasmic for AMACR, nuclear for p63, and cytoplasmic for CK5/6
Regulatory status: IVD, FDA Class I
Product code: 8485-C010: RTU, 10 capsules; 1 pack
8485-M100: RTU, 100 tests, 1 cartridge; 1 unit


The immunohistochemical combination of nuclear p63 expression and cytoplasmic CK5/6 expression aids in detection of peripheral basal cells, while cytoplasmic expression of AMACR in glandular cells facilitates the detection of potentially neoplastic proliferations.
Tissue-Tek Genie<sup>&reg;</sup> DUO<br /> anti-AMACR/p63/CK5/6 PIN Antibody Cocktail This image of prostatic adenocarcinoma demonstrates moderate to strong cytoplasmic staining of the neoplastic glands for racemase (AMACR), in red. The absence of staining for p63 or CK5/6 indicates the lack of basal cells among these glands and supports the diagnosis
of adenocarcinoma.

This example of a kidney stained with the PIN Antibody Cocktail demonstrates strong cytoplasmic staining for racemase (AMACR) in red, among proximal tubules. There is no staining among distal tubules or glomeruli for AMACR. No renal structures show reactivity for p63 or CK5/6.

An example of benign hyperplastic prostate glands. The presence of nuclear staining for p63 and cytoplasmic staining for CK5/6, both in brown, demonstrates the presence of basal cells and supports a benign process. Staining for AMACR (red cytoplasmic reactivity) is negative in this image, as is typical of benign hyperplasia.
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