mouse and rabbit monoclonal
tonsil, appendix, liver, carcinoma
cytoplasmic and some membraneous staining for cytokeratins and membraneous and cytoplasmic staining for CD31
Regulatory status: IVD, FDA Class I
8484-C010: RTU, 10 capsules; 1 pack
8484-M100: RTU, 100 tests, 1 cartridge; 1 unit
Cytokeratins (CK) are a group of intermediate filament proteins expressed in cells of epithelial origin. CD31, also known as platelet/endothelial cell adhesion molecule 1 (PECAM-1), is a transmembrane protein expressed on endothelial cells and is considered to be a pan-endothelial cell marker.
Moderate to strong cytoplasmic and membraneous reactivity for cytokeratins, in brown, is seen among collecting duct epithelial cells and parietal epithelial cells of Bowman’s capsule. Moderate to strong cytoplasmic reactivity for CD31,
in red, is seen among endothelial cells of glomeruli
and within larger vessels.
Moderate to strong cytoplasmic and membraneous reactivity for cytokeratins, in brown, is seen among hepatocytes. Moderate to strong cytoplasmic reactivity for CD31, in red, is seen among sinusoidal endothelial cells.
o brown cytoplasmic reactivity for cytokeratins is seen in this cerebrum, while endothelial cells of small vessels show strong red cytoplasmic and membrane reactivity for CD31.