stomach, small Intestine, colon, appendix, myogenic tumors with know alpha actin expression
Regulatory status: IVD, FDA Class I
8292-C010: RTU, 10 capsules; 1 pack
8292-M250: RTU, 250 tests, 1 cartridge; 1 unit
Actins are cytoskeletal proteins that are involved in cell motility and are universally expressed by, and highly conserved in, all eukaryotic cells. Most cell types express the beta and gamma actins, which are involved in internal cell motility. The alpha actins are found mainly in muscle tissues where they comprise part of the contractile apparatus.
Strong cytoplasmic reactivity for Smooth Muscle Actin is seen in the smooth muscle layers and vascular walls of this appendix specimen.
Perisinusoidal cells of the liver show moderate to strong reactivity for Smooth Muscle Actin. The hepatocytes are negative.
The neural and glial elements show no reactivity for Smooth Muscle Actin. In contrast, the small vessel walls show a strong cytoplasmic reaction.