appendix, bone marrow, liver and selected cases of AML
membraneous and cytoplasmic
Regulatory status: IVD, FDA Class I
8503-C010: RTU, 10 capsules; 1 pack
8503-M250: RTU, 250 tests, 1 cartridge; 1 unit
CD13 is a heavily glycosylated membrane protein expressed by most cells of myeloid origin including monocytes, macrophages, granulocytes, and their hematopoietic precursors. CD13 is also abundantly expressed in the brush border of epithelial cells (e.g., renal proximal tubules, small intestine, prostatic epithelial cells), bile duct canaliculi, mast cells, bone marrow stromal cells, osteoclasts, in fibroblasts, and smooth muscle cells.
The squamous epithelial cells of skin show no reactivity for CD13.
A strong membraneous and cytoplasmic staining pattern is seen in among the blast cells of this AML M4 involving the bone marrow.
A strong cytoplasmic and membrane expression pattern is seen for CD13 among the proximal renal tubules.