tonsil, appendix, kidney, classical Hodgkin lymphoma, and lung adenocarcinoma
cytoplasmic and membraneous
Regulatory status: IVD, FDA Class I
8256-C010: RTU, 10 capsules; 1 pack
8256-M250: RTU, 250 tests, 1 cartridge; 1 unit
CD15 is a membrane protein expressed by most terminally differentiated myeloid cells. Activated lymphocytes are CD15 protein positive, but the majority of lymphocytes are CD15 protein negative.
Distal tubules in a normal kidney specimen are negative, while the proximal tubules show moderate cytoplasmic and strong membraneous staining for CD15.
The superficial aspect of the squamous epithelium in this esophageal specimen shows weak to moderate cytoplasmic and membraneous reactivity for CD15, while the underlying submucosal layers show scattered myeloid cells with strong cytoplasmic reactivity.
Hodgkin and Reed-Sternberg cells in this example
of classical Hodgkin lymphoma show strong Golgi staining (dot-like pattern), as well moderate to strong membrane staining. Background myeloid elements are strongly positive, while lymphocytes are negative.