Tissue-Tek Genie®

Clone: EP64
Host clonality: rabbit monoclonal
Control tissue: tonsil, lymph node
Staining pattern: membraneous
Regulatory status: IVD, FDA Class I
Product code: 8260-C010: RTU, 10 capsules; 1 pack
8260-M250: RTU, 250 tests, 1 cartridge; 1 unit


CD21 is a membrane protein that serves as the receptor for complement component C3 (C3d) and the Epstein-Barr Virus (EBV). CD21 is expressed on dendritic cells and mature B-cells.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-CD21 Moderate membraneous expression of CD21 is present on the neoplastic lymphocytes in this chronic lymphocytic lymphoma (CLL/SLL), and the benign follicular dendritic cells show strong membraneous expression.

Follicular dendritic cells within reactive follicles in this tonsil show strong membraneous staining for CD21. There is weak to moderate staining among the B-cells of the mantle zone.
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