Tissue-Tek Genie®

Clone: GM038
Host clonality: mouse monoclonal
Control tissue: appendix, myeloma, and plasmacytoma
Staining pattern: membraneous and cytoplasmic
Regulatory status: IVD, FDA Class I
Product code: 8277-C010: RTU, 10 capsules; 1 pack
8277-M250: RTU, 250 tests, 1 cartridge; 1 unit


CD38 protein is expressed on a wide range of cells with the highest expression levels typically seen in plasma cells. CD38 protein is found on immature cells of the B-cell and T-cell lineages, but is absent from most mature, resting peripheral lymphocytes.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-CD38 Moderate to strong membraneous and cytoplasmic staining for CD38 is demonstrated in this plasmacytoma.

Moderate membraneous and cytoplasmic staining for CD38 is seen in the germinal center B-cells of this normal tonsil. Strong staining is seen among plasma cells, and a range of staining intensity is seen among other hematopoetic elements.

The neoplastic cells of this diffuse large B-cell lymphoma are negative for CD38, while scattered non-neoplastic hematopoetic cells are positive.
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