Tissue-Tek Genie®

Clone: MRQ-42
Host clonality: rabbit monoclonal
Control tissue: tonsil, appendix, liver
Staining pattern: membraneous and cytoplasmic
Regulatory status: IVD, FDA Class I
Product code: 8274-C010: RTU, 10 capsules; 1 pack
8274-M250: RTU, 250 tests, 1 cartridge; 1 unit


CD56, also known as neuronal cell adhesion molecule (NCAM), is a membrane protein expressed in neurons and glial cells of the central nervous system, nerves and neuromuscular junctions of the peripheral nervous system, most types of neuroendocrine cells, various epithelial cells, smooth muscle cells, osteoblasts, natural killer (NK) cells and NK-like T-cells.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-CD56 Intense membraneous reactivity is seen in peripheral nerves, scattered mucosal neuroendocrine cells, NK-cells and a subset of T-cells in the appendix. Weaker reactivity is seen in a subpopulation of smooth muscle cells.

Strong membraneous staining is seen in NK cells and a subset of T-cells in this tonsil. Fibroblastic reticular cells show moderate expression with both a membraneous and cytoplasmic pattern.

Pancreatic exocrine cells are negative while those of neuroendocrine lineage are positive.
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