Clone: NK1
Host clonality: mouse monoclonal
Control tissue: lymph node and tonsil
Staining pattern: membraneous
Regulatory status: IVD, FDA Class I
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Product code:
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8338-C010: RTU, 10 capsules; 1 pack
8338-M250: RTU, 250 tests, 1 cartridge; 1 unit
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CD57 is expressed on subtypes of T-cells, natural killer (NK) cells, and other peripheral blood mononuclear cells. CD57 is also present in glial cells, a variety of other neural and epithelial cells, as well as various neural tumors. In addition, CD57 is expressed in prostate tissue, prostate adenocarcinoma, papillary thyroid carcinomas and thymomas.
CD57 is highly expressed in neural tissues and a strong membraneous expression pattern is seen among neurons and glial elements in this normal cerebrum.
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A moderate to strong membraneous staining reaction for CD57 is seen among NK cells and a subset of CD8+ T-cells, as shown in the germinal center of this tonsil.
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The cortical cells of this adrenal gland show a negative staining reaction for CD57, while the medullary cells show intense membraneous reactivity.