Clone: ZM33
Host clonality: mouse monoclonal
Control tissue: bone marrow, AML
Staining pattern: cytoplasmic
Regulatory status: IVD, FDA Class I
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Product code:
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8518-C010: RTU, 10 capsules; 1 pack
8518-M250: RTU, 250 tests, 1 cartridge; 1 unit
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CD61 (platelet glycoprotein IIIa, GPIIIa) is expressed in platelets and megakaryocytes, as well as endothelial cells, monocytes, smooth muscle cells, some B-cells, macrophages, mast cells, osteoclasts, and fibroblasts.
Varying degrees of cytoplasmic reactivity for CD61 are seen among several components of normal spleen including, B-cells, monocytes, mast cells, endothelial cells and platelets.
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Moderate cytoplasmic reactivity for CD61 is seen among some neurons and axons in the cerebrum.
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The neoplastic cells of this bone marrow, largely replaced with AML-M1, show no reactivity for CD61. However, background megakaryocytes and platelets show a strong granular cytoplasmic reaction for CD61.