bone marrow, AML
Regulatory status: IVD, FDA Class I
8518-C010: RTU, 10 capsules; 1 pack
8518-M250: RTU, 250 tests, 1 cartridge; 1 unit
CD61 (platelet glycoprotein IIIa, GPIIIa) is expressed in platelets and megakaryocytes, as well as endothelial cells, monocytes, smooth muscle cells, some B-cells, macrophages, mast cells, osteoclasts, and fibroblasts.
Varying degrees of cytoplasmic reactivity for CD61 are seen among several components of normal spleen including, B-cells, monocytes, mast cells, endothelial cells and platelets.
Moderate cytoplasmic reactivity for CD61 is seen among some neurons and axons in the cerebrum.
The neoplastic cells of this bone marrow, largely replaced with AML-M1, show no reactivity for CD61. However, background megakaryocytes and platelets show a strong granular cytoplasmic reaction for CD61.