Tissue-Tek Genie®
anti-Cytokeratin HMW

Clone: 34bE12
Host clonality: Mouse monoclonal
Control tissue: tonsil, esophagus, prostate
Staining pattern: cytoplasmic
Regulatory status: IVD, FDA Class I
Product code: 8306-C010: RTU, 10 capsules; 1 pack
8306-M250: RTU, 250 tests, 1 cartridge; 1 unit


Human high molecular weight cytokeratins (CK HMW) is a term that collectively refers to the basic cytokeratins 1 through cytokeratin 6 and the acidic cytokeratins cytokeratin 9 through cytokeratin 17. Among those, CK HMW clone 34bE12 recognizes cytokeratin 1, 5, 10, and 14. These cytokeratins are expressed in various epithelial basal cells and mesothelial cells.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-Cytokeratin HMW Strong cytoplasmic reactivity of basal cells with CK HMW is present in this example of prostatic adenomatous hyperplasia. The secretory epithelium is negative. Invasive prostatic carcinoma is typified by the absence of basal cells. Hence a negative reaction for CK HMW among atypical glands would be supportive of invasive carcinoma, although it is not
seen in this case.

Hepatocytes show no reactivity for CK HMW, while there is an intense cytoplasmic reactivity among bile ducts.
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