Tissue-Tek Genie®
anti-Cytokeratin 18

Clone: DC10
Host clonality: mouse monoclonal
Control tissue: liver, gastrointestinal tract, and known CK 18 positive tumors
Staining pattern: cytoplasmic and sometimes membraneous
Regulatory status: IVD, FDA Class I
Product code: 8302-C010: RTU, 10 capsules; 1 pack
8302-M250: RTU, 250 tests, 1 cartridge; 1 unit


Cytokeratin 18 (CK18) is expressed in simple, non-stratified epithelia, in transitional epithelium, and in the luminal/secretory cells of complex epithelia. It is often co-expressed with CK8.
Tissue-Tek Genie<sup>&reg; </sup><br /> anti-Cytokeratin 18 Strong cytoplasmic and membrane staining is present in the mucosal epithelium of the appendix.
Weak to moderate cytoplasmic and membraneous reactivity for CK18 is seen in subsets of hepatocytes. Stronger staining is present in the vicinity of the portal tracts. Bile ducts show strong staining.

The squamous epithelium in this skin biopsy is negative for CK18, while a glandular structure in the lower left is strongly positive.
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