Tissue-Tek Genie®
anti-Cytokeratin 5/6

Clone: D5/16B4
Host clonality: mouse monoclonal
Control tissue: tonsil, esophagus, prostate
Staining pattern: cytoplasmic
Regulatory status: IVD, FDA Class I
Product code: 8295-C010: RTU, 10 capsules; 1 pack
8295-M250: RTU, 250 tests, 1 cartridge; 1 unit


Keratins 5 and 6 (CK5/6) are high molecular weight cytokeratins that are expressed in various epithelial basal cells and mesothelial cells.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-Cytokeratin 5/6 Strong cytoplasmic staining is observed among the basal cells of benign prostate glands. Luminal epithelium and stromal smooth muscle are negative.

Negative staining with CK5/6 among invasive carcinoma glands corresponds to the absence of basal cells in the tumor. Basal cells are preserved in the benign glands and prostate intraepithelial neoplasia.

Hepatocytes, bile ducts, sinusoids and vascular structures are all negative for CK5/6.
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