liver, gastrointestinal tract, and known CK8 positive tumors
cytoplasmic and sometimes membraneous
Regulatory status: IVD, FDA Class I
8238-C010: RTU, 10 capsules; 1 pack
8238-M250: RTU, 250 tests, 1 cartridge; 1 unit
Cytokeratin 8 (CK8) is low molecular weight cytokeratin that is often co-expressed with cytokeratin 18. Cytokeratin 8 is expressed in simple, non-stratified epithelia, in transitional epithelium, and in the luminal/secretory cells of complex epithelia.
Strong membraneous and cytoplasmic reactivity for CK8 is seen among the columnar epithelial cells of the appendix.
Weak to moderate cytoplasmic and membraneous staining for CK8 is seen in normal hepatocytes, with stronger staining among the hepatocytes of periportal areas.
The simple epithelium of these glands show strong membraneous and cytoplasmic CK8 reactivity, while the overlying squamous epithelium shows only weak reactivity in the basal aspect.