Clone: AE1/AE3
Host clonality: mouse monoclonal
Control tissue: normal liver, esophagus, lung
Staining pattern: cytoplasmic
Regulatory status: IVD, FDA Class I
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Product code:
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8307-C010: RTU, 10 capsules; 1 pack
8307-M250: RTU, 250 tests, 1 cartridge; 1 unit
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Cytokeratins are a group of intermediate filament proteins expressed in cells of epithelial origin. The antibody cocktail of clones AE1 and AE3 labels both acidic and basic cytokeratins in normal and neoplastic cells.
![Tissue-Tek Genie<sup>®</sup><br /> anti-Cytokeratin Antibody Cocktail [AE1/AE3]](/getattachment/2ff26c10-e01c-4f76-924d-f7c1e3a11b29/File-Name "Tissue-Tek Genie<sup>®</sup><br /> anti-Cytokeratin Antibody Cocktail [AE1/AE3]")
The AE1/AE3 cocktail shows strong cytoplasmic and membraneous staining in this high-grade neuroendocrine carcinoma of lung. Patchy golgi (dot-like) staining is also observed.
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The antibody cocktail, AE1/AE3, shows moderate cytoplasmic and membraneous reactivity in the hepatocytes of normal liver, with strong cytoplasmic staining of bile ducts.