Tissue-Tek Genie®
anti-Cytokeratin LMW (CK8/18) Antibody Cocktail [EP17/DC10]

Clone: EP17/DC10
Host clonality: rabbit and mouse monoclonal
Control tissue: liver, GI tract, esophagus, and known cytokeratin LMW (CK8/18) positive tumors
Staining pattern: cytoplasmic and sometimes membraneous
Regulatory status: IVD, FDA Class I
Product code: 8298-C010: RTU, 10 capsules; 1 pack
8298-M250: RTU, 250 tests, 1 cartridge; 1 unit


Cytokeratins 8 and 18 are often co-expressed in glandular and transitional epithelial cells in liver and intestine.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-Cytokeratin LMW (CK8/18) Antibody Cocktail [EP17/DC10] Strong cytoplasmic and membraneous reactivity for CK8/18 is observed in simple epithelia, as in this example of colon.

Variable levels of cytoplasmic and membraneous reactivity for CK8/18 are present among hepatocytes, with greater degrees of staining in the periportal zones.

In contrast to the strong cytoplasmic reactivity present in the simple glandular epithelium, below, the stratified squamous epithelium of the esophagus shows weak to negative cytoplasmic reactivity for CK8/18, with the greatest degree of intensity in the basal region.
Back to top