Clone: EP17/DC10
Host clonality: rabbit and mouse monoclonal
Control tissue: liver, GI tract, esophagus, and known cytokeratin LMW (CK8/18) positive tumors
Staining pattern: cytoplasmic and sometimes membraneous
Regulatory status: IVD, FDA Class I
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Product code:
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8298-C010: RTU, 10 capsules; 1 pack
8298-M250: RTU, 250 tests, 1 cartridge; 1 unit
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Cytokeratins 8 and 18 are often co-expressed in glandular and transitional epithelial cells in liver and intestine.
![Tissue-Tek Genie<sup>®</sup><br /> anti-Cytokeratin LMW (CK8/18) Antibody Cocktail [EP17/DC10]](/getattachment/5fe637b7-8894-43b8-9112-1562d3f9811b/File-Name "Tissue-Tek Genie<sup>®</sup><br /> anti-Cytokeratin LMW (CK8/18) Antibody Cocktail [EP17/DC10]")
Strong cytoplasmic and membraneous reactivity for CK8/18 is observed in simple epithelia, as in this example of colon.
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Variable levels of cytoplasmic and membraneous reactivity for CK8/18 are present among hepatocytes, with greater degrees of staining in the periportal zones.
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In contrast to the strong cytoplasmic reactivity present in the simple glandular epithelium, below, the stratified squamous epithelium of the esophagus shows weak to negative cytoplasmic reactivity for CK8/18, with the greatest degree of intensity in the basal region.