Clone: EP111
Host clonality: rabbit monoclonal
Control tissue: appendix, tonsil, ERG positive prostate carcinoma
Staining pattern: nucrear
Regulatory status: IVD, FDA Class I
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Product code:
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8323-C010: RTU, 10 capsules; 1 pack
8323-M250: RTU, 250 tests, 1 cartridge; 1 unit
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Erythroblast transformation-specific transcription factor (ERG) is expressed in endothelial cells of blood and lymphatic vessels, and bone marrow stem cells. In particular, the TMPRSS2-ERG fusion gene is found in
45-65% of prostate cancers. ERG is expressed in endothelial neoplasms including hemangioendothelioma, angiosarcoma and Kaposi sarcoma. Clone EP111 is also named as EPR3864. This clone is capable of detecting both wild-type and truncated ERG.
This prostate carcinoma shows strong nuclear expression of ERG. The benign ducts in the background
are negative.
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The lymphocytes in this tonsil specimen show weak to moderate nuclear reactivity for ERG. The background endothelial cells show strong nuclear reactivity, while the focus of squamous epithelium is negative.
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Fallopian tube epithelium shows no reactivity for ERG, while endothelial cells show strong nuclear reactivity.