appendix, tonsil, ERG positive prostate carcinoma
Regulatory status: IVD, FDA Class I
8323-C010: RTU, 10 capsules; 1 pack
8323-M250: RTU, 250 tests, 1 cartridge; 1 unit
Erythroblast transformation-specific transcription factor (ERG) is expressed in endothelial cells of blood and lymphatic vessels, and bone marrow stem cells. In particular, the TMPRSS2-ERG fusion gene is found in
45-65% of prostate cancers. ERG is expressed in endothelial neoplasms including hemangioendothelioma, angiosarcoma and Kaposi sarcoma. Clone EP111 is also named as EPR3864. This clone is capable of detecting both wild-type and truncated ERG.
This prostate carcinoma shows strong nuclear expression of ERG. The benign ducts in the background
The lymphocytes in this tonsil specimen show weak to moderate nuclear reactivity for ERG. The background endothelial cells show strong nuclear reactivity, while the focus of squamous epithelium is negative.
Fallopian tube epithelium shows no reactivity for ERG, while endothelial cells show strong nuclear reactivity.