Urothelial carcinoma typically demonstrates moderate to strong nuclear reactivity for GATA3.


Weak to moderate nuclear reactivity for GATA3 is seen in the T-cells of the T-zones, as well as T-cells of the germinal centers. B-cells are negative. The overlying tonsillar squamous epithelium is negative.


GATA3 is negative among the tubules and stromal elements of the kidney, while collecting ducts and glomerular podocytes show strong nuclear staining.