Tissue-Tek Genie®

Clone: EP368
Host clonality: rabbit monoclonal
Control tissue: tonsil, kidney, breast
Staining pattern: nuclear
Regulatory status: IVD, FDA Class I
Product code: 8242-C010: RTU, 10 capsules; 1 pack
8242-M250: RTU, 250 tests, 1 cartridge; 1 unit


GATA binding protein 3 (GATA3) is a transcription factor involved in regulating development in multiple tissues.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-GATA3 Urothelial carcinoma typically demonstrates moderate to strong nuclear reactivity for GATA3.

Weak to moderate nuclear reactivity for GATA3 is seen in the T-cells of the T-zones, as well as T-cells of the germinal centers. B-cells are negative. The overlying tonsillar squamous epithelium is negative.

GATA3 is negative among the tubules and stromal elements of the kidney, while collecting ducts and glomerular podocytes show strong nuclear staining.
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