Tissue-Tek Genie®

Clone: EP95
Host clonality: rabbit monoclonal
Control tissue: skin, GCDFP-15 positive breast and breast carsinoma
Staining pattern: cytoplasmic
Regulatory status: IVD, FDA Class I
Product code: 8325-C010: RTU, 10 capsules; 1 pack
8325-M250: RTU, 250 tests, 1 cartridge; 1 unit


Gross cystic disease fluid protein-15 (GCDFP-15) is a secretory glycoprotein and is expressed in the acinic cells of the breast, salivary glands, sweat glands, and seminal vesicle. GCDFP-15 is often expressed in neoplastic cells of breast carcinomas (50-70%), mammary and extramammary Paget’s disease, sweat gland tumors (particularly apocrine), and salivary gland tumors.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-GCDFP-15 Diffuse strong cytoplasmic reactivity for GCDFP-15
is observed in this invasive ductal carcinoma of breast.

Scattered cells in this ductal carcinoma of breast show weak to moderate cytoplasmic reactivity for GCDFP-15. Additionally, some reactive material is seen in extracellular spaces, particularly gland lumens.

The appendiceal epithelium and underlying elements of the lamina propria, and muscularis, show no reactivity for GCDFP-15.
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