Clone: EP230
Host clonality: rabbit monoclonal
Control tissue: spleen, tonsil, selected T-cell lymphomas
Staining pattern: cytoplasmic, granular
Regulatory status: IVD, FDA Class I
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Product code:
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8234-C010: RTU, 10 capsules; 1 pack
8234-M250: RTU, 250 tests, 1 cartridge; 1 unit
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Granzyme B is a serine protease expressed by cytotoxic T-lymphocytes and natural killer cells. It induces apoptosis in target cells of these lymphocytes.
Moderate to strong coarsely granular cytoplasmic reactivity for Granzyme B is observed in the neoplastic cells of this peripheral T-cell lymphoma involving bone marrow.
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Scattered lymphocytes in the spleen show coarsely granular cytoplasmic reactivity for Granzyme B.
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The neoplastic lymphocytes of this B-CLL involving the bone marrow show no reactivity for Granzyme B.