tonsil or lymph nodes or selected B-cell neoplasms
membraneous and cytoplasmic
Regulatory status: IVD, FDA Class I
8382-C010: RTU, 10 capsules; 1 pack
8382-M250: RTU, 250 tests, 1 cartridge; 1 unit
In normal, healthy serum, IgD is generally the fourth most abundant of the immunoglobulin heavy-chain classes. Immunoglobulin (Igs) are produced in mature B-cells and plasma cells, and the amount and type of Ig can vary in different stages of B-cell maturation: Igs in the earlier stages of maturation are present in the cytoplasm, whereas surface expression of Igs is more characteristic of mature B-cells in the mantle zone.
A subset of germinal center B-cells show weak to moderate predominantly cytoplasmic reactivity for IgD, while the mantle zone B-cells show strong membraneous and cytoplasmic staining.
The neural and glial elements of the cerebrum show a negative staining reaction for IgD, while a weak staining for extracellular IgD within intravascular spaces is often seen.