tonsil, lymph node or selected B-cell neoplasms
Regulatory status: IVD, FDA Class I
8383-C010: RTU, 10 capsules; 1 pack
8383-M250: RTU, 250 tests, 1 cartridge; 1 unit
In normal healthy serum, IgG is the most abundant of the Ig classes. Igs are produced in mature B-cells and plasma cells, and the amount and type of Ig can vary in different stages of B-cell maturation: in the earlier stages of maturation, Igs are present in the cytoplasm, whereas surface expression of Igs is more characteristic of mature B-cells in the mantle zone.
In the germinal centers of tonsil and lymph nodes, a strong staining reaction for IgG is observed in the cytoplasm of plasma cells, and weak to moderate staining in the cytoplasm and membrane of immunoblasts in the germinal centers.
Neural and glial elements in the cerebrum show no staining reaction for IgG, while some staining is observed in vessel lumens.