tonsil, parotid gland, IgG4 related sclerosing pancreatitis
Regulatory status: IVD, FDA Class I
8384-C010: RTU, 10 capsules; 1 pack
8384-M250: RTU, 250 tests, 1 cartridge; 1 unit
Immunoglobulin (Ig) consists of two identical heavy chains (γ, or μ, or α, or δ, or ε) and two identical light chains (kappa or lambda). IgG is the most abundant immunoglobulin and has several subclasses (IgG1, 2, 3, and 4). IgG4-related sclerosing disease (IgG-RD) is a fibroinflammatory and a multi-system disorder characterized by elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells.
An increased proportion of IgG4 positive plasma cells are present in this case of IgG4-related sclerosing pancreatitis. The cells show a strong cytoplasmic staining reaction.
Rare IgG4 positive plasma cells in the lamina propria of this appendix show a strong cytoplasmic staining reaction.
There is no IgG4 staining reaction in this section of normal pancreas.