Clone: polyclonal
Host clonality: rabbit polyclonal
Control tissue: tonsil, lymph node, and kappa light chain protein positive B-cell neoplasms
Staining pattern: membraneous and cytoplsmic
Regulatory status: IVD, FDA Class I
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Product code:
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8394-C010: RTU, 10 capsules; 1 pack
8394-M250: RTU, 250 tests, 1 cartridge; 1 unit
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Amounts and types of immunoglobulin (Ig) monomers can vary in different stages of B-cell maturation. Igs are expressed in the cytoplasm (early stage of maturation, plasma cells) or on the membrane (B-cells in the mantle zone). Neoplasms such as B-cell lymphoma and plasma cell myeloma may be demonstrated to be clonal when they produce only one type of Ig light chain.
Strong membraneous reactivity for Ig Kappa is seen among the neoplastic cells of this B-cell CLL.
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No expression of Kappa light chains is observed in this example of B-CLL/SLL. Scattered non-neoplastic plasma cells are strongly Kappa positive.