Regulatory status: IVD, FDA Class I
8324-C010: RTU, 10 capsules; 1 pack
8324-M250: RTU, 1 cartridge, 250 tests; 1 unit
MLH1 is expressed in normal proliferating cells and, when hetero-dimerized with PMS2 (Postmeiotic segregation increased 2), is involved in repairing DNA mutations which may occur during DNA replication. Lost expression or low levels of MLH1 are associated with colorectal and other cancers.
Strong staining of normal appendix.
Strong staining of colon adenocarcinoma.
Negative staining of colon adenocarcinoma with loss of MLH1 expression.