Tissue-Tek Genie®

Clone: GM011
Host clonality: mouse monoclonal
Control tissue: normal colon
Staining pattern: nuclear
Regulatory status: IVD, FDA Class I
Product code: 8324-C010: RTU, 10 capsules; 1 pack
8324-M250: RTU, 1 cartridge, 250 tests; 1 unit


MLH1 is expressed in normal proliferating cells and, when hetero-dimerized with PMS2 (Postmeiotic segregation increased 2), is involved in repairing DNA mutations which may occur during DNA replication. Lost expression or low levels of MLH1 are associated with colorectal and other cancers.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-MLH1 Strong staining of normal appendix.

Strong staining of colon adenocarcinoma.

Negative staining of colon adenocarcinoma with loss of MLH1 expression.
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