Tissue-Tek Genie®

Clone: EP190
Host clonality: rabbit monoclonal
Control tissue: tonsil, appendix, B-cell lymphoma, and myeloma
Staining pattern: nuclear
Regulatory status: IVD, FDA Class I
Product code: 8329-C010: RTU, 10 capsules; 1 pack
8329-M250: RTU, 250 tests, 1 cartridge; 1 unit


Multiple Myeloma Oncogene 1 (MUM1) protein is expressed at the later stages of B-cell development and can be demonstrated in B-cells in the light zone of lymphoid germinal centers, plasma cells, a subpopulation of activated T-cells, and some melanocytes. MUM1 protein is expressed in many B-cell lymphomas, myelomas, and some melanocytic tumors.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-MUM-1 Strong nuclear and weak cytoplasmic reactivity for MUM1 is present in this non-GCB diffuse large B-cell lymphoma.

Variable reactivity for MUM1 is seen in this tonsil, including weak to moderate nuclear reactivity in the marginal and mantle zone B-cells, and strong nuclear reactivity among plasma cells within the germinal center and the interfollicular areas.

The neoplastic cells of this germinal center B-cell (GCB) diffuse large B-cell lymphoma show no nuclear reactivity for MUM1. Scattered benign plasma cells show a strong nuclear reaction.
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