bone marrow, tonsil, liver, and myeloid leukemias
Regulatory status: IVD, FDA Class I
8407-C010: RTU, 10 capsules; 1 pack
8407-M250: RTU, 250 tests, 1 cartridge; 1 unit
Myeloperoxidase (MPO) is a peroxidase enzyme involved in antimicrobial activity. MPO is synthesized and expressed in precursor and mature granulocytes, including neutrophils and eosinophils, and is variably expressed in monocytes/macrophages.
The neoplastic cells of this example of acute myeloid leukemia (AML-M1) involving bone marrow, show diffuse strong granular cytoplasmic reactivity for MPO.
The neoplastic cells of this mantle cell lymphoma show no reactivity for MPO.
Hepatocytes show no, or only weak, cytoplasmic granular staining for MPO. Kupffer cells are strongly positive for a granular cytoplasmic staining reaction.