Tissue-Tek Genie®
anti-Myeloperoxidase (MPO)

Clone: EP151
Host clonality: rabbit monoclonal
Control tissue: bone marrow, tonsil, liver, and myeloid leukemias
Staining pattern: granular cytoplasmic
Regulatory status: IVD, FDA Class I
Product code: 8407-C010: RTU, 10 capsules; 1 pack
8407-M250: RTU, 250 tests, 1 cartridge; 1 unit


Myeloperoxidase (MPO) is a peroxidase enzyme involved in antimicrobial activity. MPO is synthesized and expressed in precursor and mature granulocytes, including neutrophils and eosinophils, and is variably expressed in monocytes/macrophages.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-Myeloperoxidase (MPO) The neoplastic cells of this example of acute myeloid leukemia (AML-M1) involving bone marrow, show diffuse strong granular cytoplasmic reactivity for MPO.

The neoplastic cells of this mantle cell lymphoma show no reactivity for MPO.

Hepatocytes show no, or only weak, cytoplasmic granular staining for MPO. Kupffer cells are strongly positive for a granular cytoplasmic staining reaction.
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