Tissue-Tek Genie®
anti-Myosin Smooth Muscle

Clone: SMMS-1
Host clonality: mouse monoclonal
Control tissue: breast, tonsil, appendix
Staining pattern: cytoplasmic
Regulatory status: IVD, FDA Class I
Product code: 8517-C010: RTU, 10 capsules; 1 pack
8517-M250: RTU, 250 tests, 1 cartridge; 1 unit


Myosin is one of the major contractile proteins in muscle and non-muscle cells. A Myosin molecule consists of two heavy chains (MHCs) and two pairs of light chains. MHCs have multiple isoforms. This antibody reacts with the smooth muscle myosin heavy chain, which is encoded by the MYH11 gene. Smooth muscle myosin heavy chain is expressed in visceral and vascular smooth muscle cells as well as myoepithelial cells.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-Myosin Smooth Muscle The myoepithelial cells of these breast ducts and lobules show a strongly positive cytoplasmic staining reaction for smooth muscle myosin heavy chain.

The smooth muscle stroma of this prostate with adenomatous hyperplasia shows moderate to strong cytoplasmic reactivity. Note that the basal cells of these glands show no staining reaction, as they are not myoepithelial cells.

The cortical epithelial cells of the adrenal gland show no staining reaction for smooth muscle myosin heavy chain.
A small vessel lined by smooth muscle shows a strong granular cytoplasmic staining reaction.
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