appendix, colon, and tumors with neuronal differentation
Regulatory status: IVD, FDA Class I
8289-C010: RTU, 10 capsules; 1 pack
8289-M250: RTU, 250 tests, 1 cartridge; 1 unit
Neurofilaments are cytoskeletal proteins normally found in neurons and axonal processes, and often found in tumors of neural, neuroendocrine, and endocrine origin, including neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, paragangliomas, adrenal and extra-adrenal pheochromocytomas, and Merkel cell carcinoma.
Strong cytoplasmic reactivity for Neurofilaments is observed in the axons of benign peripheral nerve, while smooth muscle and vascular elements show no reactivity.
Moderate to strong cytoplasmic reactivity for Neurofilaments is seen in the neoplastic cells of this malignant peripheral nerve sheath tumor (MPNST).
The squamous epithelium and underlying basal cell carcinoma show no reactivity for neurofilaments. Vascular elements and fibroblasts are also negative, while scattered nerve axons are positive.