kidney, endometrium, PAX8 positive RCC, and ono-mucineous ovarian cancer
Regulatory status: IVD, FDA Class I
8502-C010: RTU, 10 capsules; 1 pack
8502-M250: RTU, 250 tests, 1 cartridge; 1 unit
PAX8 is a transcription factor that is important for organogenesis and development of the thyroid, urogenital tract, and placenta. PAX8 is expressed in epithelial cells of the urogenital tract and thyroid.
PAX8 shows diffuse strong nuclear and weak cytoplasmic expression in an ovarian serous carcinoma (shown here), as well as other non-mucinous ovarian carcinomas.
The PAX8 antibody shows moderate to strong nuclear staining among renal cell carcinoma cells.
This antibody is negative among B-cells of the tonsil, unlike several other antibodies raised against the N-terminus of the PAX8 protein.