Tissue-Tek Genie®

Clone: EP298
Host clonality: rabbit monoclonal
Control tissue: kidney, endometrium, PAX8 positive RCC, and ono-mucineous ovarian cancer
Staining pattern: nuclear
Regulatory status: IVD, FDA Class I
Product code: 8502-C010: RTU, 10 capsules; 1 pack
8502-M250: RTU, 250 tests, 1 cartridge; 1 unit


PAX8 is a transcription factor that is important for organogenesis and development of the thyroid, urogenital tract, and placenta. PAX8 is expressed in epithelial cells of the urogenital tract and thyroid.
Tissue-Tek Genie<sup>&reg; </sup><br /> anti-PAX8 PAX8 shows diffuse strong nuclear and weak cytoplasmic expression in an ovarian serous carcinoma (shown here), as well as other non-mucinous ovarian carcinomas.

The PAX8 antibody shows moderate to strong nuclear staining among renal cell carcinoma cells.

This antibody is negative among B-cells of the tonsil, unlike several other antibodies raised against the N-terminus of the PAX8 protein.
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