Tissue-Tek Genie®

Clone: EP51
Host clonality: rabbit monoclonal
Control tissue: normal colon, appendix, tonsil
Staining pattern: nuclear
Regulatory status: IVD, FDA Class I
Product code: 8328-C010: RTU, 10 capsules; 1 pack
8328-M250: RTU, 1 cartridge, 250 tests; 1 unit


PMS2 is expressed in normal proliferating cells and, when heterodimerized with MLH1 (MutL protein homolog 1), is involved in repairing DNA mutations which may occur during DNA replication. Lost expression or low levels of PMS2 are associated with colorectal and other cancers.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-PMS2 Strong staining in colon adenocarcinoma.

Moderate staining in normal appendix.

Negative staining in colon adenocarcinoma cells with loss of PMS2 expression.
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