Tissue-Tek Genie®

Clone: D2-40
Host clonality: mouse monoclonal
Control tissue: tonsil, appendix, lymph node, epithelioid mesothelioma
Staining pattern: mainly cytoplasmic and some membraneous
Regulatory status: IVD, FDA Class I
Product code: 8515-C010: RTU, 10 capsules; 1 pack
8515-M250: RTU, 250 tests, 1 cartridge; 1 unit


Podoplanin is a transmembrane protein expressed by lymphatic endothelial cells, fibroblasts, osteocytes, follicular dendritic cells, smooth and striated muscle cells, myoepithelial cells, Cajal cells, squamous epithelial basal cells, prostatic basal epithelial cells, immature Sertoli cells, gastric crypt cells, renal glomerular podocytes, and Schwann cells. In tumors, podoplanin is detected in follicular dendritic cell tumors, dermatofibromas, lymphangiomas, Kaposi’s sarcoma, hemangioblastomas, seminomas, epithelioid mesotheliomas, and a subset of angiosarcomas with lymphatic differentiation.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-Podoplanin Podoplanin shows strong, predominantly membraneous, reactivity in this epithelioid mesothelioma.

Podoplanin demonstrates weak to moderate membrane staining in this ovarian serous carcinoma.

Podoplanin is negative in this primary lung carcinoma. Lymphatic endothelium shows cytoplasmic and membraneous staining.
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