tonsil, appendix, lymph node, epithelioid mesothelioma
mainly cytoplasmic and some membraneous
Regulatory status: IVD, FDA Class I
8515-C010: RTU, 10 capsules; 1 pack
8515-M250: RTU, 250 tests, 1 cartridge; 1 unit
Podoplanin is a transmembrane protein expressed by lymphatic endothelial cells, fibroblasts, osteocytes, follicular dendritic cells, smooth and striated muscle cells, myoepithelial cells, Cajal cells, squamous epithelial basal cells, prostatic basal epithelial cells, immature Sertoli cells, gastric crypt cells, renal glomerular podocytes, and Schwann cells. In tumors, podoplanin is detected in follicular dendritic cell tumors, dermatofibromas, lymphangiomas, Kaposi’s sarcoma, hemangioblastomas, seminomas, epithelioid mesotheliomas, and a subset of angiosarcomas with lymphatic differentiation.