skin, gastrointestinal tract, melanoma
cytoplasmic and nuclear
Regulatory status: IVD, FDA Class I
8442-C010: RTU, 10 capsules; 1 pack
8442-M250: RTU, 1 cartridge, 250 tests; 1 unit
S100 is a multigene family of calcium binding proteins. S100B is one member of the S100 family and is expressed in glial cells of nervous system, melanocytes, chondrocytes, and adipocytes. The antibody labels S100B in normal and neoplastic cells.
Strong staining in malignant melanoma.
Strong staining of macrophages, Schwann cells, and ganglionic cells in muscularis propria and submucosa in appendix.
No staining of columnar epithelial cells in colon adenocarcinoma, but positive staining of macrophages in supporting stroma.