epidermis, colon, melanoma
Regulatory status: IVD, FDA Class I
8264-C010: RTU, 10 capsules; 1 pack
8264-M250: RTU, 1 cartridge, 250 tests; 1 unit
SOX10 is a neural crest transcription factor involved in the determination of cell fate, maturation, and maintenance of Schwann cells and melanocytes. The antibody labels SOX10 in both normal and neoplastic cells.
Strong staining in malignant melanoma.
No staining in colon adenocarcinoma.
Strong staining in isolated melanocytes located in the basal layer of epidermis.