selected mantle cell lymphomas
Regulatory status: IVD, FDA Class I
8521-C010: RTU, 10 capsules; 1 pack
8521-M250: RTU, 250 tests, 1 cartridge; 1 unit
Sry-related HMg-box gene 11 (SOX11) is a nuclear transcription factor expressed in the developing human central nervous system and plays a role in embryonic cell determination. SOX11 is not expressed in normal adult human tissues. SOX11 over-expression is reported in over 90% of mantle cell lymphomas, including the rare cyclin D1-negative cases. SOX11 expression has also been identified in other tumors including malignant gliomas, neuroendocrine carcinomas, sarcomas, adenocarcinomas, lymphoblastic leukemias /lymphomas, Burkitt lymphomas and hairy cell leukemias.
Strong nuclear reactivigty for SOX11 is seen in the neoplastic cells of this mantle cell lymphoma.
A moderate nuclear staining reaction for SOX11 is seen in this example of mantle cell lymphoma.
No reactivity for SOX11 is seen among the normal elements of this benign tonsil.