Tissue-Tek Genie®

Clone: CM032
Host clonality: mouse monoclonal
Control tissue: selected mantle cell lymphomas
Staining pattern: nuclear
Regulatory status: IVD, FDA Class I
Product code: 8521-C010: RTU, 10 capsules; 1 pack
8521-M250: RTU, 250 tests, 1 cartridge; 1 unit


Sry-related HMg-box gene 11 (SOX11) is a nuclear transcription factor expressed in the developing human central nervous system and plays a role in embryonic cell determination. SOX11 is not expressed in normal adult human tissues. SOX11 over-expression is reported in over 90% of mantle cell lymphomas, including the rare cyclin D1-negative cases. SOX11 expression has also been identified in other tumors including malignant gliomas, neuroendocrine carcinomas, sarcomas, adenocarcinomas, lymphoblastic leukemias /lymphomas, Burkitt lymphomas and hairy cell leukemias.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-SOX11 Strong nuclear reactivigty for SOX11 is seen in the neoplastic cells of this mantle cell lymphoma.

A moderate nuclear staining reaction for SOX11 is seen in this example of mantle cell lymphoma.

No reactivity for SOX11 is seen among the normal elements of this benign tonsil.
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