Clone: EP103
Host clonality: rabbit monoclonal
Control tissue: embryonal carcinoma, esophagus, SCC, tonsil
Staining pattern: nuclear
Regulatory status: IVD, FDA Class I
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Product code:
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8228-C010: RTU, 10 capsules; 1 pack
8228-M250: RTU, 250 tests, 1 cartridge; 1 unit
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Sry-related HMg-box gene 2 (SOX2) is expressed in multipotent neuronal stem cells in normal tissues. Overexpression of SOX2 is found in testicular germ cell tumors, teratomas, astrocytic tumors, melanomas, various squamous cell carcinomas, and breast cancers with a basal cell phenotype.
Moderate to strong nuclear staining and weak to moderate granular cytoplasmic expression is present in this embryonal carcinoma.
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Moderate to strong nuclear staining is seen in scattered spermatogonia. Other tissue elements are negative.
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This seminoma is negative for nuclear SOX2 staining.