Tissue-Tek Genie®
anti-Terminal Deoxyribonucleotidyl Transferase

Clone: SEN28
Host clonality: mouse monoclonal
Control tissue: thymus, thymoma, some cells within tonsils
Staining pattern: nuclear
Regulatory status: IVD, FDA Class I
Product code: 8243-C010: RTU, 10 capsules; 1 pack
8243-M250: RTU, 250 tests, 1 cartridge; 1 unit


Terminal deoxynucleotidyl transferase (TdT) is a deoxynucleotide polymerizing enzyme that generates antigen receptor diversity at the junctions of rearranged immunoglobulin heavy chain and T-cell receptor gene segments. TdT protein expression is normally found only in B-cell and T-cell lymphoblasts/lymphoid progenitor cells. TdT protein-positive cells are regularly detected in thymus and bone marrow, and may occasionally be seen in tonsils, lymph nodes, and extranodal lymphoid tissue.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-Terminal Deoxyribonucleotidyl Transferase Strong staining of the infiltrating immature T-cells is seen in this thymoma.
The neoplastic epithelial component is negative.

Mature T- and B-cells of the tonsil are negative for TdT. Scattered immature T-Cells of the interfollicular areas may show strong nuclear staining.
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