kidney, fallopian tube, and serous carcinomas
Nuclear staining is interpreted as positive. Nucleolar staining and/or membraneous staining alone are not considered positive
Regulatory status: IVD, FDA Class I
8340-C010: RTU, 10 capsules; 1 pack
8340-M250: RTU, 250 tests, 1 cartridge; 1 unit
Wilms’ tumor-1 protein (WT1) is a transcription factor that plays a role in the development of genitourinary organs and is involved in the induction of Wilms’ tumor (nephroblastoma), a pediatric renal malignancy. It is largely restricted to the surface epithelium and inclusion cysts of ovaries and fallopian tubes, and is absent in endometrial and cervical epithelia.
Strong nuclear expression of WT1 is characteristic of serous carcinoma, as seen in the above image.
Moderate to strong nuclear reactivity for WT1 is present in the podocytes and parietal epithelial cells of the
Lung adenocarcinoma is negative for nuclear WT1 expression (nucleolar reactivity is interpreted as negative).