Clone: ZM97
Host clonality: mouse monoclonal
Control tissue: lymph node, tonsil, selected cases of B-CLL/SLL
Staining pattern: cytoplasmic and nuclear
Regulatory status: IVD, FDA Class I
Product code:
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8501-C010: RTU, 10 capsules; 1 pack
8501-M250: RTU, 250 tests, 1 cartridge; 1 unit
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ZAP70 is expressed in T-cells, natural killer (NK) cells, and pro/pre B-cells, but not in normal mature B-cells. Expression of ZAP70 has been reported in various lymphomas, including mantle cell lymphoma, marginal zone lymphoma, and approximately 25% of chronic lymphocytic leukemias. In CLL, ZAP70 expression is closely associated with an unmutated configuration of the IgVH genes.
Cytoplasmic and nuclear staining are observed in the neoplastic cells of this nodal T-cell lymphoma.
The neoplastic cells of this acute myeloid leukemia (M5) show no staining for ZAP70, while in the background scattered T-cells and immature B-cells are positive for strong nuclear and cytoplasmic reactivity.
No staining for ZAP70 is seen among the neoplastic epithelial cells or stroma in this colorectal carcinoma.