Tissue-Tek Genie®

Clone: ZM97
Host clonality: mouse monoclonal
Control tissue: lymph node, tonsil, selected cases of B-CLL/SLL
Staining pattern: cytoplasmic and nuclear
Regulatory status: IVD, FDA Class I
Product code: 8501-C010: RTU, 10 capsules; 1 pack
8501-M250: RTU, 250 tests, 1 cartridge; 1 unit


ZAP70 is expressed in T-cells, natural killer (NK) cells, and pro/pre B-cells, but not in normal mature B-cells. Expression of ZAP70 has been reported in various lymphomas, including mantle cell lymphoma, marginal zone lymphoma, and approximately 25% of chronic lymphocytic leukemias. In CLL, ZAP70 expression is closely associated with an unmutated configuration of the IgVH genes.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-ZAP70 Cytoplasmic and nuclear staining are observed in the neoplastic cells of this nodal T-cell lymphoma.

The neoplastic cells of this acute myeloid leukemia (M5) show no staining for ZAP70, while in the background scattered T-cells and immature B-cells are positive for strong nuclear and cytoplasmic reactivity.

No staining for ZAP70 is seen among the neoplastic epithelial cells or stroma in this colorectal carcinoma.
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