tonsil, c-Myc positive B-cell lymphoma
Regulatory status: IVD, FDA Class I
8332-C010: RTU, 10 capsules; 1 pack
8332-M250: RTU, 250 tests, 1 cartridge; 1 unit
C-Myc is expressed during proliferation in a wide variety of adult tissues and at all stages of embryonic development. C-Myc gene translocations to various chromosomal loci have been demonstrated in Burkitt lymphoma, diffuse large B-cell lymphoma, blastic mantle cell lymphoma, and transformed follicular lymphoma. C-Myc expression has been described in various cancers including lymphomas, breast, prostate, lung and colon cancers.
Diffuse, moderate to strong nuclear reactivity for c -Myc is observed in this diffuse large B-cell lymphoma.
Epithelial cells of this benign fallopian tube show a weak to moderate nuclear c-Myc staining reaction.
Acinar epithelial cells of this normal pancreas show a negative staining reaction, or only focal faint staining, for c-Myc.