tonsil, liver and neoplastic breast epithelial cells of lobular type (showing loss of membrane reactivity)
membraneous staining of normal cells, membraneous and cytoplasmic staining of some neoplastic cells
Regulatory status: IVD, FDA Class I
8373-C010: RTU, 10 capsules; 1 pack
8373-M250: RTU, 250 tests, 1 cartridge; 1 unit
p120 catenin binds E-Cadherin at a juxta-membrane site while alpha-catenin and beta-catenin bind to the intracellular domain of E-Cadherin. A deficiency of E-Cadherin results in the intracytoplasmic accumulation of p120 catenin. Diffuse cytoplasmic p120 catenin staining (without strong membraneous staining) is seen in in situ and invasive lobular carcinoma and other lesions with dysfunctional E-cadherin / catenin tight junctions.
Strong membraneous and moderate to strong cytoplasmic staining for p120 catenin is seen in normal breast ducts and lobules. By contrast, lobular carcinoma (in situ and invasive) shows a loss of membrane staining with an accumulation of cytoplasmic protein.
A moderate membraneous staining reaction for p120 is observed among hepatocytes, while bile ducts demonstrate an intense membrane staining pattern.
Neural and glial elements in the cerebrum show no staining reaction for p120 catenin.