tonsil, prostate, placenta, and squamous cell carcinoma
Regulatory status: IVD, FDA Class I
8312-C010: RTU, 10 capsules; 1 pack
8312-M250: RTU, 250 tests, 1 cartridge; 1 unit
P63 is a transcription factor that plays a critical role in the growth and development of many epithelial tissues. It is found in basal epithelial cells in tissues such as cervix, bladder, breast, epidermis, and prostate.
Strong nuclear expression for p63 is present in the majority of neoplastic cells in this squamous cell carcinoma of lung. Weak nuclear reactivity is also discernable in scattered lymphocytes.
Moderate to strong nuclear reactivity for p63 is seen among the squamous epithelial cells of the tonsil, while scattered lymphocytes may also show weak nuclear reactivity.
The neoplastic cells of this lung adenocarcinoma show no reactivity for p63. Scattered entrapped benign bronchial reserve cells show nuclear reactivity for p63.